Ubiquitination, a pivotal posttranslational modification of proteins, plays a fundamental role
in regulating protein stability. The dysregulation of ubiquitinating and deubiquitinating …

Dynamic modulation and posttranslational modification of proteins are tightly controlled
biological processes that occur in response to physiological cues. One such dynamic …

Rapid protein degradation enables cells to quickly modulate protein abundance.
Dysregulation of short-lived proteins plays essential roles in disease pathogenesis. A …

The F-box and WD-repeat-containing protein 2 (FBXW2) plays a crucial role as an E3 ligase
in regulating tumorigenesis. However, the functions of FBXW2 in breast cancer are still …

The tumor microenvironment (TME) plays an important role in neoplastic development.
Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of …

Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for
various cellular processes whose dysregulation is linked to serious diseases including …

The Wnt signaling pathway plays important roles in embryonic development, homeostatic
processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β …

Drug resistance is the major obstacle of gemcitabine-based chemotherapy for the treatment
of pancreatic ductal adenocarcinoma (PDAC). Many long non-coding RNAs (lncRNAs) are …

FBXO28 is a member of F-box proteins that are the substrate receptors of SCF (SKP1,
CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the implications of its role in …

Oncogene Moesin plays critical role in initiation, progression, and metastasis of multiple
cancers. It exerts oncogenic activity due to its high-level expression as well as …