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Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism
Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating
effects of young blood on aged tissues. However, the specific rejuvenating mechanisms …
effects of young blood on aged tissues. However, the specific rejuvenating mechanisms …
NAD+ metabolism, stemness, the immune response, and cancer
LE Navas, A Carnero - Signal transduction and targeted therapy, 2021 - nature.com
NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …
[HTML][HTML] New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis
Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …
NAD+ intermediates: the biology and therapeutic potential of NMN and NR
Research on the biology of NAD+ has been gaining momentum, providing many critical
insights into the pathogenesis of age-associated functional decline and diseases. In …
insights into the pathogenesis of age-associated functional decline and diseases. In …
Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-
associated metabolic complications. However, the molecular links between lipid-overloaded …
associated metabolic complications. However, the molecular links between lipid-overloaded …
[HTML][HTML] MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives
Background Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from
simple hepatic steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which may …
simple hepatic steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which may …
Molecular and cellular mechanisms of cardiovascular disorders in diabetes
The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
Physiological and pathophysiological roles of NAMPT and NAD metabolism
Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular
nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential coenzyme involved in …
nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential coenzyme involved in …