Therapeutic cancer vaccines: advancements, challenges and prospects

T Fan, M Zhang, J Yang, Z Zhu, W Cao… - Signal Transduction and …, 2023 - nature.com
With the development and regulatory approval of immune checkpoint inhibitors and adoptive
cell therapies, cancer immunotherapy has undergone a profound transformation over the …

Lactate in the regulation of tumor microenvironment and therapeutic approaches

KG de la Cruz-López, LJ Castro-Muñoz… - Frontiers in …, 2019 - frontiersin.org
Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Phagocytosis checkpoints as new targets for cancer immunotherapy

M Feng, W Jiang, BYS Kim, CC Zhang, YX Fu… - Nature Reviews …, 2019 - nature.com
Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …

Novel strategies for cancer immunotherapy: counter-immunoediting therapy

S Liu, Q Sun, X Ren - Journal of Hematology & Oncology, 2023 - Springer
The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Cancer epigenetics, tumor immunity, and immunotherapy

J Cao, Q Yan - Trends in cancer, 2020 - cell.com
Epigenetic mechanisms, including DNA methylation, histone post-translational
modifications, and chromatin structure regulation, are critical for the interactions between …

Engineered T cells: the promise and challenges of cancer immunotherapy

AD Fesnak, CH June, BL Levine - Nature reviews cancer, 2016 - nature.com
The immune system evolved to distinguish non-self from self to protect the organism. As
cancer is derived from our own cells, immune responses to dysregulated cell growth present …

Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

S Wang, Z He, X Wang, H Li, XS Liu - Elife, 2019 - elifesciences.org
Immunotherapy, represented by immune checkpoint inhibitors (ICI), is transforming the
treatment of cancer. However, only a small percentage of patients show response to ICI, and …

[HTML][HTML] Cancer immunotherapy: opportunities and challenges in the rapidly evolving clinical landscape

LA Emens, PA Ascierto, PK Darcy, S Demaria… - European journal of …, 2017 - Elsevier
Cancer immunotherapy is now established as a powerful way to treat cancer. The recent
clinical success of immune checkpoint blockade (antagonists of CTLA-4, PD-1 and PD-L1) …

p53, cancer and the immune response

J Blagih, MD Buck, KH Vousden - Journal of cell science, 2020 - journals.biologists.com
The importance of cancer-cell-autonomous functions of the tumour suppressor p53
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …

[HTML][HTML] Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation

H Xu, K Van der Jeught, Z Zhou, L Zhang, T Yu… - The Journal of clinical …, 2021 - jci.org
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity,
which arises due to lack of immunogenic tumor antigens as well as dysregulation of the …