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Renal thrombotic microangiopathy: a review
Thrombotic microangiopathy (TMA), a pathological lesion observed in a wide spectrum of
diseases, is triggered by endothelial injury and/or dysfunction. Although TMA lesions are …
diseases, is triggered by endothelial injury and/or dysfunction. Although TMA lesions are …
[HTML][HTML] Myeloperoxidase: regulation of neutrophil function and target for therapy
SA Rizo-Téllez, M Sekheri, JG Filep - Antioxidants, 2022 - mdpi.com
Neutrophils, the most abundant white blood cells in humans, are critical for host defense
against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils …
against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils …
NETosis, complement, and coagulation: a triangular relationship
CM de Bont, WC Boelens, GJM Pruijn - Cellular & molecular …, 2019 - nature.com
NETosis is a regulated form of neutrophil cell death that contributes to the host defense
against pathogens and was linked to various diseases soon after its first description in 2004 …
against pathogens and was linked to various diseases soon after its first description in 2004 …
Pathophysiology of inflammatory bowel disease: innate immune system
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis
(UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause …
(UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause …
Production of complement components by cells of the immune system
R Lubbers, MF Van Essen… - Clinical & …, 2017 - academic.oup.com
The complement system is an important part of the innate immune defence. It contributes not
only to local inflammation, removal and killing of pathogens, but it also assists in sha** of …
only to local inflammation, removal and killing of pathogens, but it also assists in sha** of …
[HTML][HTML] Neutrophil extracellular trap formation: physiology, pathology, and pharmacology
Neutrophil extracellular traps (NETs), a unique DNA framework decorated with antimicrobial
peptides, have been in the scientific limelight for their role in a variety of pathologies ranging …
peptides, have been in the scientific limelight for their role in a variety of pathologies ranging …
Roles of neutrophil granule proteins in orchestrating inflammation and immunity
Neutrophil granulocytes form the first line of host defense against invading pathogens and
tissue injury. They are rapidly recruited from the blood to the affected sites, where they …
tissue injury. They are rapidly recruited from the blood to the affected sites, where they …
Cytokines in inflammatory bowel diseases–update 2020
M Leppkes, MF Neurath - Pharmacological Research, 2020 - Elsevier
Abstract Inflammatory Bowel Diseases (IBD), namely Crohn's Disease and Ulcerative Colitis,
cause a significant disease burden in modern civilization. Ever since the introduction of anti …
cause a significant disease burden in modern civilization. Ever since the introduction of anti …
Mechanisms of haemolysis-induced kidney injury
Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …
haemolytic anaemias, including those associated with haemoglobinopathies, complement …
In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review
Background Multiple inducers of in vitro Neutrophil Extracellular Trap (NET) formation
(NETosis) have been described. Since there is much variation in study design and results …
(NETosis) have been described. Since there is much variation in study design and results …