A perspective on multi-target drugs for Alzheimer's disease

O Benek, J Korabecny, O Soukup - Trends in pharmacological sciences, 2020 - cell.com
Alzheimer's disease (AD) has a complex pathophysiology that includes aggregation of
pathological proteins, impaired neurotransmission, increased oxidative stress, or microglia …

Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress

Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Alzheimer's disease pharmacotherapy in relation to cholinergic system involvement

GD Stanciu, A Luca, RN Rusu, V Bild… - Biomolecules, 2019 - mdpi.com
Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

[HTML][HTML] Tea and coffee polyphenols and their biological properties based on the latest in vitro investigations

P Liczbiński, B Bukowska - Industrial crops and products, 2022 - Elsevier
Tea and coffee contain numerous polyphenolic compounds that exhibit health-promoting
properties for humans, including antioxidant and neuroprotective properties, and can also …

[HTML][HTML] Chemical composition, antioxidant and enzyme inhibitory properties of different extracts obtained from spent coffee ground and coffee silverskin

G Zengin, KI Sinan, MF Mahomoodally, S Angeloni… - Foods, 2020 - mdpi.com
In a world where an eco-friendlier approach is becoming more and more necessary, it is
essential to reduce waste production and to reuse residues of the company's supply chain …

Neuroprotective effects of cholinesterase inhibitors: current scenario in therapies for Alzheimer's disease and future perspectives

NCS Moreira, JEBF Lima… - Journal of …, 2022 - journals.sagepub.com
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease
conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to …

Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer's disease

DE Hafez, M Dubiel, G La Spada, M Catto… - Journal of Enzyme …, 2023 - Taylor & Francis
Neurodegenerative diseases such as Alzheimer's disease (AD) are multifactorial with
several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed …

New 3d multifunctional metal chelates of sulfonamide: spectral, vibrational, molecular modeling, DFT, medicinal and in silico studies

AU Hassan, SH Sumrra, M Imran, ZH Chohan - Journal of Molecular …, 2022 - Elsevier
We are reporting a new synthetic design of sulfonamide entangled Schiff base ligands as H
2 L 1 and H 2 L 2 from 4-amino-N-(3-methyl-1, 2-oxazol-5-yl) benzene-1-sulfonamide and …

[HTML][HTML] Photobiomodulation in Alzheimer's disease—A complementary method to state-of-the-art pharmaceutical formulations and nanomedicine?

LM Ailioaie, C Ailioaie, G Litscher - Pharmaceutics, 2023 - mdpi.com
Alzheimer's disease (AD), as a neurodegenerative disorder, usually develops slowly but
gradually worsens. It accounts for approximately 70% of dementia cases worldwide, and is …

Metal incorporated sulfonamides as promising multidrug targets: Combined enzyme inhibitory, antimicrobial, antioxidant and theoretical exploration

SH Sumrra, AU Hassan, MN Zafar, SS Shafqat… - Journal of Molecular …, 2022 - Elsevier
In this report, new sulfonamide based ligands (L 1)-(L 3) from 4-amino-N-(pyrimidin-2-yl)
benzene-1-sulfonamide are synthesized and branded on the basis of their physical …