Role of inflammatory cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to …
AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a severe pandemic of the current century. The vicious …
coronavirus 2 (SARS-CoV-2), is a severe pandemic of the current century. The vicious …
Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine
S Cajander, M Kox, BP Scicluna… - The Lancet …, 2024 - thelancet.com
Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …
recognition of its significance, immune status monitoring is not implemented in clinical …
Artificial intelligence in sepsis early prediction and diagnosis using unstructured data in healthcare
Sepsis is a leading cause of death in hospitals. Early prediction and diagnosis of sepsis,
which is critical in reducing mortality, is challenging as many of its signs and symptoms are …
which is critical in reducing mortality, is challenging as many of its signs and symptoms are …
An immune-cell signature of bacterial sepsis
Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition
with high mortality. Multiple whole-blood gene-expression studies have defined sepsis …
with high mortality. Multiple whole-blood gene-expression studies have defined sepsis …
Sepsis biomarkers and diagnostic tools with a focus on machine learning
Over the last years, there have been advances in the use of data-driven techniques to
improve the definition, early recognition, subtypes characterisation, prognostication and …
improve the definition, early recognition, subtypes characterisation, prognostication and …
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …
priority. There has been a tremendous effort to decipher underlying mechanisms …
Prognostic and predictive enrichment in sepsis
NL Stanski, HR Wong - Nature Reviews Nephrology, 2020 - nature.com
Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …
Unsupervised analysis of transcriptomics in bacterial sepsis across multiple datasets reveals three robust clusters
Objectives: To find and validate generalizable sepsis subtypes using data-driven clustering.
Design: We used advanced informatics techniques to pool data from 14 bacterial sepsis …
Design: We used advanced informatics techniques to pool data from 14 bacterial sepsis …
Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults
We carried out integrated host and pathogen metagenomic RNA and DNA next generation
sequencing (mNGS) of whole blood (n= 221) and plasma (n= 138) from critically ill patients …
sequencing (mNGS) of whole blood (n= 221) and plasma (n= 138) from critically ill patients …
The potential of using blood circular RNA as liquid biopsy biomarker for human diseases
Circular RNA (circRNA) is a novel class of single-stranded RNAs with a closed loop
structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA …
structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA …