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Innate lymphoid cells and innate-like T cells in cancer—at the crossroads of innate and adaptive immunity
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …
many cancers, yet only a subset of patients benefit from these approaches. A better …
MAIT cell activation and functions
TSC Hinks, XW Zhang - Frontiers in immunology, 2020 - frontiersin.org
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict
conservation across 150 million years of mammalian evolution, implying they must fulfill …
conservation across 150 million years of mammalian evolution, implying they must fulfill …
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
S Notarbartolo, V Ranzani, A Bandera, P Gruarin… - Science …, 2021 - science.org
To understand how a protective immune response against SARS-CoV-2 develops over time,
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function
Increasing evidence indicates close interaction between immune cells and the brain,
revising the traditional view of the immune privilege of the brain. However, the specific …
revising the traditional view of the immune privilege of the brain. However, the specific …
Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing
A Du Halgouet, A Darbois, M Alkobtawi, M Mestdagh… - Immunity, 2023 - cell.com
Tissue repair processes maintain proper organ function following mechanical or infection-
related damage. In addition to antibacterial properties, mucosal associated invariant T …
related damage. In addition to antibacterial properties, mucosal associated invariant T …
MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis
Y El Morr, M Fürstenheim, M Mestdagh… - Science …, 2024 - science.org
Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors
and responds to such changes remains unclear. Here, we describe a protective mechanism …
and responds to such changes remains unclear. Here, we describe a protective mechanism …
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients
Y Jouan, A Guillon, L Gonzalez, Y Perez… - Journal of Experimental …, 2020 - rupress.org
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute
respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a …
respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a …
TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions
T Leng, HD Akther, CP Hackstein, K Powell, T King… - Cell reports, 2019 - cell.com
MAIT cells are an unconventional T cell population that can be activated through both TCR-
dependent and TCR-independent mechanisms. Here, we examined the impact of …
dependent and TCR-independent mechanisms. Here, we examined the impact of …
[HTML][HTML] MAIT cells, guardians of skin and mucosa?
Abstract Mucosal Associated Invariant T (MAIT) cells are evolutionary conserved innate-like
T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis …
T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis …