Adipokines in nonalcoholic fatty liver disease
Since the discovery of adipose tissue as a higly active endocrine tissue, adipokines,
peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine …
peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine …
The role of apelin–APJ system in diabetes and obesity
C Li, H Cheng, BK Adhikari, S Wang, N Yang… - Frontiers in …, 2022 - frontiersin.org
Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the
world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts …
world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts …
Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling
J Duan, J Cui, Z Yang, C Guo, J Cao, M **… - Journal of …, 2019 - Springer
Background Previous studies had showed that Apelin 13 could protect against apoptosis
induced by ischemic/reperfusion (I/R). However, the mechanisms whereby Apelin 13 …
induced by ischemic/reperfusion (I/R). However, the mechanisms whereby Apelin 13 …
Apelin and energy metabolism
C Bertrand, P Valet, I Castan-Laurell - Frontiers in physiology, 2015 - frontiersin.org
A wide range of adipokines identified over the past years has allowed considering the white
adipose tissue as a secretory organ closely integrated into overall physiological and …
adipose tissue as a secretory organ closely integrated into overall physiological and …
Elabela-apelin receptor signaling pathway is functional in mammalian systems
Elabela (ELA) or Toddler is a recently discovered hormone which is required for normal
development of heart and vasculature through activation of apelin receptor (APJ), a G …
development of heart and vasculature through activation of apelin receptor (APJ), a G …
Elucidating solution structures of cyclic peptides using molecular dynamics simulations
Protein–protein interactions are vital to biological processes, but the shape and size of their
interfaces make them hard to target using small molecules. Cyclic peptides have shown …
interfaces make them hard to target using small molecules. Cyclic peptides have shown …
International union of basic and clinical pharmacology. CVII. Structure and pharmacology of the apelin receptor with a recommendation that elabela/toddler is a …
The predicted protein encoded by the APJ gene discovered in 1993 was originally classified
as a class AG protein-coupled orphan receptor but was subsequently paired with a novel …
as a class AG protein-coupled orphan receptor but was subsequently paired with a novel …
[HTML][HTML] CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis
The intricate molecular landscape of cancer pathogenesis continues to captivate
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …
[HTML][HTML] Apelinergic system structure and function
Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …
[HTML][HTML] Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases
The apelin/apelin receptor system is widely distributed and has a dominant role in
cardiovascular homeostasis and disease. The apelin gene is X-linked and is synthesized as …
cardiovascular homeostasis and disease. The apelin gene is X-linked and is synthesized as …