Macrophages are effector cells of the innate immune system that phagocytose bacteria and
secrete both pro-inflammatory and antimicrobial mediators. In addition, macrophages play …

Overweight and obesity are now considered a worldwide pandemic and a growing public
health problem with severe economic and social consequences. Adipose tissue is an organ …

Background Neuroinflammation is an important secondary injury mechanism that has dual
beneficial and detrimental roles in the pathophysiology of traumatic brain injury (TBI) …

The effects of fasting-mimicking diet (FMD) cycles in reducing many aging and disease risk
factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles …

Doxorubicin (Dox)-induced cardiac side effects are regulated through increased oxidative
stress and apoptosis. However, it remains unknown whether Dox induces the specific …

Microglia cells are the unique residential macrophages of the central nervous system (CNS).
They have a special origin, as they derive from the embryonic yolk sac and enter the …

Regulatory T cells (Tregs) are known to protect against ischemic stroke. However, the low
frequency of Tregs restricts their clinical utility. This study investigated whether expanding …

Aging-related especially brain aging-related diseases are heavy health care burdens
worldwide. Natural products with antioxidant and anti-inflammatory properties have been …

The blood–brain barrier (BBB) is an important physiologic barrier that separates CNS from
soluble inflammatory mediators and effector immune cells from peripheral circulation. The …

Traumatic brain injury (TBI) is a debilitating acquired neurological disorder that afflicts nearly
74 million people worldwide annually. TBI has been classified as more than just a single …