Early detection of pancreatic cancer

SP Pereira, L Oldfield, A Ney, PA Hart… - The lancet …, 2020 - thelancet.com
Pancreatic ductal adenocarcinoma is most frequently detected at an advanced stage. Such
late detection restricts treatment options and contributes to a dismal 5-year survival rate of 3 …

Roles of CA19-9 in pancreatic cancer: Biomarker, predictor and promoter

G Luo, K **, S Deng, H Cheng, Z Fan, Y Gong… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Carbohydrate antigen 19-9 (CA19-9) is the best validated biomarker and an
indicator of aberrant glycosylation in pancreatic cancer. CA19-9 functions as a biomarker …

Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised …

U Menon, A Gentry-Maharaj, M Burnell, N Singh… - The Lancet, 2021 - thelancet.com
Background Ovarian cancer continues to have a poor prognosis with the majority of women
diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of …

Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) …

M Goggins, KA Overbeek, R Brand, S Syngal… - Gut, 2020 - gut.bmj.com
Background and aim The International Cancer of the Pancreas Screening Consortium met in
2018 to update its consensus recommendations for the management of individuals with …

Isobaric labeling-based relative quantification in shotgun proteomics

N Rauniyar, JR Yates III - Journal of proteome research, 2014 - ACS Publications
Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers

J Kim, WR Bamlet, AL Oberg, KG Chaffee… - Science translational …, 2017 - science.org
Markers are needed to facilitate early detection of pancreatic ductal adenocarcinoma
(PDAC), which is often diagnosed too late for effective therapy. Starting with a PDAC cell …

Diabetes and pancreatic cancer: Exploring the two-way traffic

A Roy, J Sahoo, S Kamalanathan… - World journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Pancreatic cancer (PC) is often associated with a poor prognosis. Long-standing diabetes
mellitus is considered as an important risk factor for its development. This risk can be …

Serum biomarker signature-based liquid biopsy for diagnosis of early-stage pancreatic cancer

LD Mellby, AP Nyberg, JS Johansen… - Journal of Clinical …, 2018 - ascopubs.org
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year
survival of< 10% because of diffuse symptoms leading to late-stage diagnosis. That survival …

Analysis of the plasma proteome using iTRAQ and TMT‐based Isobaric labeling

R Moulder, SD Bhosale, DR Goodlett… - Mass spectrometry …, 2018 - Wiley Online Library
Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric
tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) …

Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?

RS O'Neill, A Stoita - World journal of gastroenterology, 2021 - pmc.ncbi.nlm.nih.gov
Pancreatic cancer (PC) is a leading cause of cancer related mortality on a global scale. The
disease itself is associated with a dismal prognosis, partly due to its silent nature resulting in …