Understanding dioxin developmental toxicity using the zebrafish model
SA Carney, AL Prasch, W Heideman… - … Research Part A …, 2006 - Wiley Online Library
Zebrafish (Danio rerio) have advantages over mammals as an animal model for
investigating developmental toxicity. 2, 3, 7, 8‐Tetrachlorodibenzo‐p‐dioxin (dioxin, TCDD) …
investigating developmental toxicity. 2, 3, 7, 8‐Tetrachlorodibenzo‐p‐dioxin (dioxin, TCDD) …
Intersection of AHR and Wnt signaling in development, health, and disease
AJ Schneider, AM Branam, RE Peterson - International journal of …, 2014 - mdpi.com
The AHR (aryl hydrocarbon receptor) and Wnt (wingless-related MMTV integration site)
signaling pathways have been conserved throughout evolution. Appropriately regulated …
signaling pathways have been conserved throughout evolution. Appropriately regulated …
[PDF][PDF] Increased prevalence of primary biliary cirrhosis near Superfund toxic waste sites
A Ala, CM Stanca, M Bu‐Ghanim, I Ahmado… - …, 2006 - Wiley Online Library
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are uncommon liver
diseases of unknown etiology. Reported clustering of PBC cases may be due to …
diseases of unknown etiology. Reported clustering of PBC cases may be due to …
Diabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult Native Americans
N Codru, MJ Schymura, S Negoita, R Rej… - Environmental …, 2007 - ehp.niehs.nih.gov
Background Recent research suggests that diabetes, a condition whose incidence is
increasing, is associated with exposure to polychlorinated biphenyls (PCBs) and chlorinated …
increasing, is associated with exposure to polychlorinated biphenyls (PCBs) and chlorinated …
Chronic exposure to low doses of dioxin promotes liver fibrosis development in the C57BL/6J diet-induced obesity mouse model
C Duval, F Teixeira-Clerc, AF Leblanc… - Environmental …, 2017 - ehp.niehs.nih.gov
Background: Exposure to persistent organic pollutants (POPs) has been associated with the
progression of chronic liver diseases, yet the contribution of POPs to the development of …
progression of chronic liver diseases, yet the contribution of POPs to the development of …
Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity
DR Boverhof, LD Burgoon, C Tashiro… - Toxicological …, 2005 - academic.oup.com
In an effort to further characterize the mechanisms of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
(TCDD)-mediated toxicity, comprehensive temporal and dose–response microarray …
(TCDD)-mediated toxicity, comprehensive temporal and dose–response microarray …
[HTML][HTML] Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes
An adverse outcome pathway (AOP) describes the causal linkage between initial molecular
events and an adverse outcome at individual or population levels. Whilst there has been …
events and an adverse outcome at individual or population levels. Whilst there has been …
Glutathione Redox State Regulates Mitochondrial Reactive OxygenProduction
D Shen, TP Dalton, DW Nebert, HG Shertzer - Journal of Biological …, 2005 - ASBMB
Oxidative stress induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is poorly
understood. Following one dose of TCDD (5 μg/kgbody weight), mitochondrial succinate …
understood. Following one dose of TCDD (5 μg/kgbody weight), mitochondrial succinate …
Mammalian adenylyl cyclase-associated protein 1 (CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion
CAP (adenylyl cyclase-associated protein) was first identified in yeast as a protein that
regulates both the actin cytoskeleton and the Ras/cAMP pathway. Although the role in Ras …
regulates both the actin cytoskeleton and the Ras/cAMP pathway. Although the role in Ras …
Microarray analysis reveals a mechanism of phenolic polybrominated diphenylether toxicity in zebrafish
Polybrominated diphenylethers (PBDEs) are ubiquitous in the environment, with the lower
brominated congener 2, 2′, 4, 4′-tetrabromodiphenylether (BDE47) among the most …
brominated congener 2, 2′, 4, 4′-tetrabromodiphenylether (BDE47) among the most …