Immune-based therapies in penile cancer

VB Joshi, PE Spiess, A Necchi, CA Pettaway… - Nature Reviews …, 2022 - nature.com
Penile cancer is a rare genitourinary malignancy that is associated with poor outcomes and
severely limited therapeutic options that are generally non-curative when used to treat …

Immunotherapeutic approaches for the treatment of HPV-associated (pre-) cancer of the cervix, vulva and penis

TS Rafael, J Rotman, OR Brouwer… - Journal of Clinical …, 2022 - mdpi.com
Human papillomavirus (HPV) infection drives tumorigenesis in almost all cervical cancers
and a fraction of vulvar and penile cancers. Due to increasing incidence and low vaccination …

Atezolizumab with or without radiotherapy for advanced squamous cell carcinoma of the penis (the PERICLES study): a phase II trial

HM de Vries, TS Rafael, A Gil-Jimenez… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Patients with advanced penile squamous cell carcinoma have a poor prognosis
(21% 2-year overall survival [OS] from diagnosis). We assessed the activity of atezolizumab …

Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors

T El Zarif, AH Nassar, GR Pond… - JNCI: Journal of the …, 2023 - academic.oup.com
Background Treatment options for penile squamous cell carcinoma are limited. We sought to
investigate clinical outcomes and safety profiles of patients with penile squamous cell …

Assessment of PD-L1, TROP2, and nectin-4 expression in penile squamous cell carcinoma

B Tekin, JC Cheville, LH Hernandez, V Negron… - Human Pathology, 2023 - Elsevier
Objectives There is an unmet need for therapeutically relevant biomarkers for advanced
penile squamous cell carcinoma (pSCC). Proposed immunohistochemistry (IHC)-based …

Pembrolizumab for advanced penile cancer: a case series from a phase II basket trial

AW Hahn, J Chahoud, MT Campbell, DD Karp… - Investigational new …, 2021 - Springer
Background: Treatment options for unresectable, locally advanced or metastatic penile
squamous cell carcinoma (SCC) are limited. Previous studies have shown that 40–62% of …

Effective combinatorial immunotherapy for penile squamous cell carcinoma

T Huang, X Cheng, J Chahoud, A Sarhan… - Nature …, 2020 - nature.com
Penile squamous cell carcinoma (PSCC) accounts for over 95% of penile malignancies and
causes significant mortality and morbidity in develo** countries. Molecular mechanisms …

The immune microenvironment in penile cancer and rationale for immunotherapy

ME Ahmed, S Falasiri, A Hajiran, J Chahoud… - Journal of clinical …, 2020 - mdpi.com
Penile cancer is an extremely rare malignancy that accounts for approximately 1% of cancer
deaths in the United States every year. While primary penile cancer can be managed …

Current management and future perspectives of penile cancer: An updated review

F Peyraud, C Allenet, M Gross-Goupil… - Cancer Treatment …, 2020 - Elsevier
Penile cancer (PeCa) is a rare disease worldwide, accounting for less than one percent of
all malignancies in men. It usually presents as a painless ulcer or lump on the head of the …

PD-L1 and p16 expression in penile squamous cell carcinoma from an endemic region

MW De Bacco, GF Carvalhal, B MacGregor… - Clinical Genitourinary …, 2020 - Elsevier
Background Penile squamous cell carcinoma (PSCC) is a rare malignancy with higher
incidence in develo** countries. Treatment options include surgery, radiation therapy, and …