Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still
remains a major life-threatening malignancy. CRC etiology entails both genetic and …

Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or
the rectum. A growing number of researches prove that the unfolded protein response (UPR) …

Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) contribute to the onset of
many neoplasias through RNA-RNA competitive interactions; in addition, they could be …

Background Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce
endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response …

Glucose regulated protein 78 (GRP78) has long been recognized as a molecular chaperone
in the endoplasmic reticulum (ER) and can be induced by the ER stress response. Besides …

Gemcitabine is currently the leading therapeutic for pancreatic cancer treatment, despite
growing resistance. Studying the mechanisms that underlie gemcitabine resistance and …

Apoptosis triggered by endoplasmic reticulum (ER) stress is associated with rapid
attenuation of the IRE1α and ATF6 pathways but persistent activation of the PERK branch of …

The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)
pathway has a master control role in various cancer-related biological processes as cell …

TRAP1 is a mitochondrial antiapoptotic protein up-regulated in several human
malignancies. However, recent evidences suggest that TRAP1 is also localized in the …

Background: Chemotherapy triggers endoplasmic reticulum (ER) stress, which in turn
regulates levels of the active (LAP) and the natural dominant-negative (LIP) forms of the …