Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining
glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of …

Cell proliferation, apoptosis, autophagy, oxidative stress and metabolic dysregulation are
the basis of many diseases. Forkhead box transcription factor O1 (FOXO1) changes in …

Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and
malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine …

A major goal in diabetes research is to find ways to enhance the mass and function of insulin
secreting β-cells in the endocrine pancreas to prevent and/or delay the onset or even …

Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests
when insulin secretion fails to cope with worsening insulin resistance. In addition to its …

Because obesity rates have increased dramatically over the past 3 decades, type 2 diabetes
has become increasingly prevalent as well. Type 2 diabetes is associated with decreased …

Aims MicroRNAs are a class of negative regulators of gene expression, which have been
shown to be involved in the development of endocrine pancreas and in the regulation of …

Investigation of cell-cycle kinetics in mammalian pancreatic β cells has mostly focused on
transition from the quiescent (G0) to G1 phase. Here, we report that centromere protein A …

Eating a “Westernized” diet high in fat and sugar leads to weight gain and numerous health
problems, including the development of type 2 diabetes mellitus (T2DM). Rodent studies …

The insulin receptor gene encodes an evolutionarily conserved signaling protein with a wide
spectrum of functions in metazoan development. The insulin signaling pathway plays key …