With increased life expectancy, women will spend over three decades of life
postmenopause. The menopausal transition increases susceptibility to metabolic diseases …

Isoflavones are phytoestrogens that have been linked to both beneficial as well as adverse
effects in relation to cell proliferation and cancer risks. The present article presents an …

Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen
receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity …

Tributyltin chloride (TBT) is an environmental contaminant used in antifouling paints of
boats. Endocrine disruptor effects of TBT are well established in animal models. However …

Sphingolipids, sphingolipid metabolizing enzymes, and their receptors network are being
recognized as part of the signaling mechanisms, which govern breast cancer cell growth …

Microstructural adaptation of bone in response to mechanical stimuli is diminished with
estrogen deprivation. Here we tested in vivo whether ovariectomy (OVX) alters the acute …

Increasing age is associated with a reduction in overall heart rate variability as well as
changes in complexity of physiologic dynamics. The aim of this study was to verify if the …

The kidney is under the influence of sexual hormones. Estrogens have a favourable role in
the progression of some chronic renal diseases. Estrogen hormones act upon the nephron …

An increasing amount of evidence points at important roles for estrogen receptors in prostate
carcinogenesis and progression. Of the two estrogen receptors, estrogen receptor β is the …

Historically, ovarian ablation (OA) was used as therapy for women with recurrent hormone-
receptor-positive (HRP) premenopausal breast cancer. With the publication of the SOFT …