Fat tissue, aging, and cellular senescence
Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in
longevity and age‐related metabolic dysfunction. Fat distribution and function change …
longevity and age‐related metabolic dysfunction. Fat distribution and function change …
Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism
Many biological programs are regulated at the transcriptional level. This is generally
achieved by the concerted actions of several transcription factors. Recent findings have …
achieved by the concerted actions of several transcription factors. Recent findings have …
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
KS Vimaleswaran, DJ Berry, C Lu, E Tikkanen… - PLoS …, 2013 - journals.plos.org
Background Obesity is associated with vitamin D deficiency, and both are areas of active
public health concern. We explored the causality and direction of the relationship between …
public health concern. We explored the causality and direction of the relationship between …
Role of mitochondrial dysfunction in insulin resistance
J Kim, Y Wei, JR Sowers - Circulation research, 2008 - Am Heart Assoc
Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …
The role of mitochondria in the pathogenesis of type 2 diabetes
The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …
association of DM with obesity and inactivity indicates an important, and potentially …
Adipose tissue, inflammation and atherosclerosis
B Gustafson - Journal of atherosclerosis and thrombosis, 2010 - jstage.jst.go.jp
Adipose tissue in mammals can be divided into white and brown adipose tissue (WAT and
BAT). WAT is not homogenous, and can be divided into subcutaneous and visceral adipose …
BAT). WAT is not homogenous, and can be divided into subcutaneous and visceral adipose …
Mitochondrial dysfunction in obesity
JC Bournat, CW Brown - Current Opinion in Endocrinology …, 2010 - journals.lww.com
Mitochondria play central roles in ATP production, energy expenditure, and disposal of ROS.
Excessive energy substrates lead to mitochondrial dysfunction with consequential effects on …
Excessive energy substrates lead to mitochondrial dysfunction with consequential effects on …
Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents
B Bjørndal, L Burri, V Staalesen, J Skorve… - Journal of …, 2011 - Wiley Online Library
Adipose tissue metabolism is closely linked to insulin resistance, and differential fat
distributions are associated with disorders like hypertension, diabetes, and cardiovascular …
distributions are associated with disorders like hypertension, diabetes, and cardiovascular …
Impaired mitochondrial biogenesis in adipose tissue in acquired obesity
Low mitochondrial number and activity have been suggested as underlying factors in
obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which …
obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which …
Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis
B Gustafson, A Hammarstedt… - … , and vascular biology, 2007 - Am Heart Assoc
The metabolic syndrome is associated with a dysregulated adipose tissue; in part a
consequence of adipose cell enlargement and the associated infiltration of macrophages …
consequence of adipose cell enlargement and the associated infiltration of macrophages …