Dynamic covalent polymers for biomedical applications

Y Zhang, Y Qi, S Ulrich, M Barboiu… - Materials chemistry …, 2020 - pubs.rsc.org
The rapid development of supramolecular polymer chemistry and constitutional dynamic
chemistry over the last decades has made tremendous impact on the emergence of dynamic …

Glycosylated gold nanoparticles in point of care diagnostics: From aggregation to lateral flow

AN Baker, GW Hawker-Bond, PG Georgiou… - Chemical Society …, 2022 - pubs.rsc.org
Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …

Self‐Assembly in Water with N‐Substituted Imines

T Jiao, G Wu, Y Zhang, L Shen, Y Lei… - Angewandte Chemie …, 2020 - Wiley Online Library
Imine synthesis has enjoyed a long history as the dynamic covalent reaction of choice for the
construction of purely covalent molecular architectures. In organic solvents, the formation of …

In situ functionalized polymers for siRNA delivery

JM Priegue, DN Crisan, J Martínez‐Costas… - Angewandte …, 2016 - Wiley Online Library
A new method is reported herein for screening the biological activity of functional polymers
across a consistent degree of polymerization and in situ, that is, under aqueous conditions …

The third orthogonal dynamic covalent bond

S Lascano, KD Zhang, R Wehlauch, K Gademann… - Chemical …, 2016 - pubs.rsc.org
Orthogonal dynamic covalent bonds are of interest for the construction of functional systems.
The orthogonality of disulfide and hydrazone exchange under basic and acidic conditions …

Combinatorial approaches in post-polymerization modification for rational development of therapeutic delivery systems

Y Zhong, BJ Zeberl, X Wang, J Luo - Acta biomaterialia, 2018 - Elsevier
The combinatorial polymer library approach has been proven to be effective for the
optimization of therapeutic delivery systems. The library of polymers with chemical diversity …

Multiprotein dynamic combinatorial chemistry: a strategy for the simultaneous discovery of subfamily‐selective inhibitors for nucleic acid demethylases FTO and …

M Das, T Yang, J Dong, F Prasetya… - Chemistry–An Asian …, 2018 - Wiley Online Library
Dynamic combinatorial chemistry (DCC) is a powerful supramolecular approach for
discovering ligands for biomolecules. To date, most, if not all, biologically templated DCC …

Molecular Recognition‐Mediated Transformation of Single‐Chain Polymer Nanoparticles into Crosslinked Polymer Films

CS Mahon, CJ McGurk, SMD Watson… - Angewandte …, 2017 - Wiley Online Library
We describe single‐chain polymer nanoparticles (SCNPs) possessing intramolecular
dynamic covalent crosslinks that can transform into polymer films through a molecular …

Enhancing the kinetics of hydrazone exchange processes: an experimental and computational study

PL Higgs, AJ Ruiz-Sanchez, M Dalmina… - Organic & …, 2019 - pubs.rsc.org
The capacity of hydrazone bonds to readily undergo component exchange processes sees
their extensive utilization in dynamic combinatorial chemistry. The kinetics of hydrazone …

Peptide and Peptidomimetic Assemblies in Dynamic Combinatorial Chemistry

A Rodrigues, L Rocard, R Moumné - ChemSystemsChem, 2023 - Wiley Online Library
A strong revival of interest has been dedicated to peptides over the last few years, in
different fields including drug discovery, biosensing and material sciences. The use of …