The alpha beta-hydrolase fold family of enzymes is rapidly becoming one of the largest
group of structurally related enzymes with diverse catalytic functions. Members in this family …

Pancreatic triglyceride lipase (P33333344) and its protein cofactor, colipase, are required for
efficient dietary triglyceride digestion. In addition to PTL, pancreatic acinar cells synthesize …

Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major
determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a …

The processing of dietary lipids can be distinguished in several sequential steps, including
their emulsification, hydrolysis and micellization, before they are absorbed by the …

Lipase inhibitors are the main anti-obesity drugs prescribed these days, but the complexity
of their mechanism of action is making it difficult to develop new molecules for this purpose …

Many enzymes are active at interfaces in the living world (such as in the signaling processes
at the surface of cell membranes, digestion of dietary lipids, starch and cellulose …

The lipid monolayer model membrane is useful for studying the parameters responsible for
protein and peptide membrane binding. Different approaches have been used to determine …

The classical human pancreatic lipase (HPL), the guinea pig pancreatic lipase-related
protein 2 (GPLRP2) and the phospholipase A1 from hornet venom (DolmI PLA1) illustrate …

Lipases catalyze the hydrolysis of triglycerides and are activated at the water− lipid interface.
Thus, their interaction with amphiphiles such as detergents is relevant for an understanding …

Although the bioavailability of dietary lipids is of primary importance in human nutrition and
health, the mechanisms involved in lipid digestion are not fully understood and are of …