Clinical impact of computational heart valve models

M Toma, S Singh-Gryzbon, E Frankini, Z Wei… - Materials, 2022 - mdpi.com
This paper provides a review of engineering applications and computational methods used
to analyze the dynamics of heart valve closures in healthy and diseased states …

Modeling dynamics of the cardiovascular system using fluid-structure interaction methods

F Syed, S Khan, M Toma - Biology, 2023 - mdpi.com
Simple Summary Fluid-structure interaction algorithms are utilized to examine how the
human circulatory system functions by simulating blood flow and capturing mechanical …

Fluid–structure interaction analyses of biological systems using smoothed-particle hydrodynamics

M Toma, R Chan-Akeley, J Arias, GD Kurgansky… - Biology, 2021 - mdpi.com
Simple Summary Computational simulations of biological systems are an intrinsic element of
engineering in medicine, allowing physicians the ability to visualize the pathophysiology …

Heart Valve Biomechanics: The Frontiers of Modeling Modalities and the Expansive Capabilities of Ex Vivo Heart Simulation

MH Park, Y Zhu, AM Imbrie-Moore, H Wang… - Frontiers in …, 2021 - frontiersin.org
The field of heart valve biomechanics is a rapidly expanding, highly clinically relevant area
of research. While most valvular pathologies are rooted in biomechanical changes, the …

Interventional planning for endovascular revision of a lateral tunnel fontan: A patient-specific computational analysis

Y Ahmed, C Tossas-Betancourt, PAJ van Bakel… - Frontiers in …, 2021 - frontiersin.org
Introduction A 2-year-old female with hypoplastic left heart syndrome (HLHS)-variant, a
complex congenital heart defect (CHD) characterized by the underdevelopment of the left …

[HTML][HTML] Computational modeling of cardiac hemodynamics including chordae tendineae, papillaries, and valves dynamics

L Bennati, A Crispino, C Vergara - Computers in Biology and Medicine, 2025 - Elsevier
In the context of dynamic image-based computational fluid dynamics (DIB-CFD) modeling of
cardiac system, the role of sub-valvular apparatus (chordae tendineae and papillary …

In Silico Analysis of the MitraClip in a Realistic Human Left Heart Model

S Pasta - Prosthesis, 2023 - mdpi.com
Mitral valve regurgitation is a common heart valve disorder associated with significant
morbidity and mortality. Transcatheter mitral valve repair using the MitraClip device has …

Addressing discrepancies between experimental and computational procedures

M Toma, SK Guru, W Wu, M Ali, CW Ong - Biology, 2021 - mdpi.com
Simple Summary This technical note addresses the need to consider uncertainties when
using experimental procedures to extract a geometry that is consequently used for …

[HTML][HTML] Post-Trauma Fetal Care Using Computational Analysis in Prenatal Surgical Guidance

AD Ashkezari, M Bekbolatova, J Mayer, T Devine… - Surgeries, 2024 - mdpi.com
The purpose of this research is to explore the biomechanical consequences of maternal
injuries on fetal movements. Additionally, the research aims to comprehend the relationship …

[HTML][HTML] Understanding traumatic brain injuries in military personnel: investigating the dynamic interplay of the cerebrospinal fluid and brain during blasts

E Frankini, EJ Basile, F Syed, OC Wei, M Toma - Cureus, 2023 - ncbi.nlm.nih.gov
Background It is estimated that around 450,000 traumatic brain injury cases have occurred
in the 21st century with possible under-reporting. Computational simulations are …