[HTML][HTML] The evolution of molecular recognition: from antibodies to molecularly imprinted polymers (MIPs) as artificial counterpart

OI Parisi, F Francomano, M Dattilo, F Patitucci… - Journal of Functional …, 2022‏ - mdpi.com
Molecular recognition is a useful property shared by various molecules, such as antibodies,
aptamers and molecularly imprinted polymers (MIPs). It allows these molecules to be …

Noncanonical functions of antibodies

JD Dimitrov, S Lacroix-Desmazes - Trends in immunology, 2020‏ - cell.com
The typical functions of antibodies are based on linking the process of antigen recognition
with initiation of innate immune reactions. With the introduction of modern research …

Catalytic Antibodies May Contribute to demyelination in myalgic Encephalomyelitis/Chronic fatigue syndrome

MA Jensen, ML Dafoe, J Wilhelmy, L Cervantes… - Biochemistry, 2023‏ - ACS Publications
Here we report preliminary data demonstrating that some patients with myalgic
encephalomyelitis/chronic fatiguesyndrome (ME/CFS) may have catalytic autoantibodies …

[HTML][HTML] Immunoglobulins with non-canonical functions in inflammatory and autoimmune disease states

EA Ermakov, GA Nevinsky, VN Buneva - International journal of molecular …, 2020‏ - mdpi.com
Immunoglobulins are known to combine various effector mechanisms of the adaptive and
the innate immune system. Classical immunoglobulin functions are associated with antigen …

Catalytic antibodies: Design, expression, and their applications in medicine

D Zhao, J Chen, X Hu, S Zhang - Applied Biochemistry and Biotechnology, 2023‏ - Springer
Catalytic antibodies made it feasible to develop new catalysts, which had previously been
the subject of research. Scientists have discovered natural antibodies that can hydrolyze …

Dengue virus nonstructural protein 1–induced antibodies cross-react with human plasminogen and enhance its activation

YC Chuang, J Lin, YS Lin, S Wang… - The Journal of …, 2016‏ - journals.aai.org
Dengue virus (DENV) infection is the most common mosquito-borne viral disease, and it can
cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome …

DNA-hydrolysing activity of IgG antibodies from the sera of patients with schizophrenia

EA Ermakov, LP Smirnova… - Open …, 2015‏ - royalsocietypublishing.org
It is believed that damage to the membranes of brain cells of schizophrenia (SCZ) patients
induces the formation of autoantigens and autoantibodies. Nevertheless, the importance of …

Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs

S von Gunten, C Schneider, L Imamovic… - Frontiers in …, 2023‏ - frontiersin.org
Significant progress has been made in the elucidation of human antibody repertoires.
Furthermore, non-canonical functions of antibodies have been identified that reach beyond …

[HTML][HTML] Catalytic antibodies in bipolar disorder: serum IgGs hydrolyze myelin basic protein

DA Kamaeva, LP Smirnova, SN Vasilieva… - International Journal of …, 2022‏ - mdpi.com
The pathogenesis of bipolar affective disorder is associated with immunological imbalances,
a general pro-inflammatory status, neuroinflammation, and impaired white matter integrity …

Autopolyreactivity confers a holistic role in the immune system

S Avrameas - Scandinavian Journal of Immunology, 2016‏ - Wiley Online Library
In this review, we summarize and discuss some key findings from the study of naturally
occurring autoantibodies. The B‐cell compartment of the immune system appears to …