Placental-related fetal growth restriction arises primarily due to deficient remodeling of the
uterine spiral arteries supplying the placenta during early pregnancy. The resultant …

Preeclampsia is becoming an increasingly common diagnosis in the developed world and
remains a high cause of maternal and fetal morbidity and mortality in the develo** world …

Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

The placenta is arguably the most important organ of the body, but paradoxically the most
poorly understood. During its transient existence, it performs actions that are later taken on …

The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …

Several histopathological features are found more frequently in placentas from pregnancies
complicated by fetal growth restriction (FGR), including villous infarction, maternal vascular …

BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Background—The exact etiology of preeclampsia is unknown, but there is growing evidence
of an imbalance in angiogenic growth factors and abnormal placentation. Hydrogen sulfide …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Preeclampsia is the cause of significant maternal and fetal mortality and morbidity. It is
characterized by new-onset hypertension and proteinuria after 20 weeks of gestation …