The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with
functions widely linked to the generation of pain. Several agonists of exogenous and …

Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …

Pain therapy has remained conceptually stagnant since the opioid crisis, which highlighted
the dangers of treating pain with opioids. An alternative addiction-free strategy to …

Our sensory adaptation to cold and chemically induced coolness is mediated by the intrinsic
property of TRPM8 channels to desensitize. TRPM8 is also implicated in cold-evoked pain …

Single particle cryo-EM often yields multiple protein conformations within a single dataset,
but experimentally deducing the temporal relationship of these conformers within a …

In the 1990s, the identification of a non-selective ion channel, especially responsive to
capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The …

Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …

The cation-permeable TRPV2 channel is important for cardiac and immune cell function.
Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few …

Chemotherapy-induced neuropathic pain (CINP) is among the most common clinical
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …