Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

R Chen, H Zhang, B Tang, Y Luo, Y Yang… - Signal transduction and …, 2024 - nature.com
The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …

Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms

Y Gui, H Zheng, RY Cao - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms

K Malekmohammad, EE Bezsonov… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial
intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways …

Role of endothelial dysfunction in cardiovascular diseases: the link between inflammation and hydrogen sulfide

HJ Sun, ZY Wu, XW Nie, JS Bian - Frontiers in pharmacology, 2020 - frontiersin.org
Endothelial cells are important constituents of blood vessels that play critical roles in
cardiovascular homeostasis by regulating blood fluidity and fibrinolysis, vascular tone …

Targeting early atherosclerosis: a focus on oxidative stress and inflammation

P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

Overview of OxLDL and its impact on cardiovascular health: focus on atherosclerosis

AV Poznyak, NG Nikiforov, AM Markin… - Frontiers in …, 2021 - frontiersin.org
Cardiovascular pathologies maintain the leading position in mortality worldwide.
Atherosclerosis is a chronic disease that can result in a variety of serious complications …

[HTML][HTML] Myricetin: A review of the most recent research

X Song, L Tan, M Wang, C Ren, C Guo, B Yang… - Biomedicine & …, 2021 - Elsevier
Myricetin (MYR) is a flavonoid compound widely found in many natural plants including
bayberry. So far, MYR has been proven to have multiple biological functions and it is a …

Targeting the microenvironment of vulnerable atherosclerotic plaques: an emerging diagnosis and therapy strategy for atherosclerosis

S Zhang, Y Liu, Y Cao, S Zhang, J Sun… - Advanced …, 2022 - Wiley Online Library
Atherosclerosis is considered one of the primary causes of cardiovascular diseases (CVDs).
Unpredictable rupture of the vulnerable atherosclerotic plaques triggers adverse …

Antioxidant properties of anthocyanins and their mechanism of action in atherosclerosis

C Garcia, CN Blesso - Free Radical Biology and Medicine, 2021 - Elsevier
Atherosclerosis develops due to lipid accumulation in the arterial wall and sclerosis as result
of increased hyperlipidemia, oxidative stress, lipid oxidation, and protein oxidation …