Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Enhancers control the location and timing of gene expression and contain the majority of
variants associated with disease,–. The ZRS is arguably the most well-studied vertebrate …

Understanding how proteins discriminate between preferred and non-preferred ligands
('selectivity') is essential for predicting biological function and a central goal of protein …

Transcription factors bind to sequence motifs and act as activators or repressors.
Transcription factors interface with a constellation of accessory cofactors to regulate distinct …

Autoactivation of lineage-determining transcription factors mediates bistable expression,
generating distinct cell phenotypes essential for complex body plans. Classical type 1 …

Enhancers have critical functions in the precise, spatiotemporal control of transcription
during development. It is thought that enhancer grammar, or the characteristics and …

Transcription factors (TFs) and cis-regulatory elements (CREs) drive organism development.
Suboptimal binding of TFs to CREs is shown to be key for the specificity of gene expression …

Individual signaling pathways, such as fibroblast growth factors (FGFs), can regulate a
plethora of inductive events. According to current paradigms, signal-dependent transcription …

Distant-acting enhancers are central to human development. However, our limited
understanding of their functional sequence features prevents the interpretation of enhancer …

Coronaviruses constitute a global threat to human and animal health. It is essential to
investigate the long-distance RNA-RNA interactions that approximate remote regulatory …