Preparation and utility of organic pentafluorosulfanyl-containing compounds

PR Savoie, JT Welch - Chemical reviews, 2015 - ACS Publications
The organic chemistry of the pentafluorosulfanyl (SF5) group, previously reviewed 1 and
extensively developed by Gard, has only recently come under more widespread …

(Hetero)aryl‐SVI Fluorides: Synthetic Development and Opportunities

M Magre, S Ni, J Cornella - Angewandte Chemie International …, 2022 - Wiley Online Library
Abstract (Hetero) arylsulfur compounds where the S atom is in the oxidation state VI
represent a large percentage of the molecular functionalities present in organic chemistry …

Chemistry of pentafluorosulfanyl derivatives and related analogs: from synthesis to applications

R Kordnezhadian, BY Li, A Zogu… - … A European Journal, 2022 - Wiley Online Library
Abstract Pentafluorosulfanyl (SF5)‐containing compounds and corresponding analogs are a
highly valuable class of fluorine‐containing building blocks owing to their unique properties …

Application of the pentafluorosulfanyl group as a bioisosteric replacement

MF Sowaileh, RA Hazlitt, DA Colby - ChemMedChem, 2017 - Wiley Online Library
The success of fluorinated molecules in drug design has led medicinal chemists to search
for new fluorine‐containing substituents. A major recently developed group is the …

Synthesis and application of pentafluorosulfanylation reagents and derived aliphatic SF5-containing building blocks

G Haufe - Tetrahedron, 2022 - Elsevier
Among the perfluorinated substituents of organic compounds, the pentafluorosulfanyl (SF 5)
group received remarkable attention in the past few decades due to its particular properties …

Polyfluorinated groups in medicinal chemistry

M Bassetto, S Ferla, F Pertusati - Future Medicinal Chemistry, 2015 - Taylor & Francis
Introduction of novel and diverse functional groups in drug discovery is always seen with
hesitancy until good activity and low toxicity characteristics are proven. The introduction of …

The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine

JT Welch, DS Lim - Bioorganic & medicinal chemistry, 2007 - Elsevier
The trifluoromethyl group of fluoxetine 1 and fenfluramine and norfenfluramine, 2 and 3, was
substituted by the pentafluorosulfanyl group. On examination of the efficacy of the …

Violation of the Franck-Condon Principle due to Recoil Effects<? format?> in High Energy Molecular Core-Level Photoionization

E Kukk, K Ueda, U Hergenhahn, XJ Liu, G Prümper… - Physical review …, 2005 - APS
Carbon 1 s photoelectron spectra of methane are measured over a photon energy range
between 480 eV and 1200 eV. Additional components appear between the individual …

Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine

P Wipf, T Mo, SJ Geib, D Caridha, GS Dow… - Organic & …, 2009 - pubs.rsc.org
Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine -
Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/B911483A Royal Society …

Pentafluorosulfanyl group: an emerging tool in optoelectronic materials

JMW Chan - Journal of Materials Chemistry C, 2019 - pubs.rsc.org
The pentafluorosulfanyl (SF5) moiety is a lesser known and underutilized functional group
that displays high electronegativity, chemical and thermal stability, and low surface energy …