Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients
B Tuka, Z Helyes, A Markovics, T Bagoly… - …, 2013 - journals.sagepub.com
Background Recent studies on migraineurs and our own animal experiments have revealed
that pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) has an important role …
that pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) has an important role …
Distinct circuits and molecular targets of the paraventricular hypothalamus decode visceral and somatic pain
YC Li, FC Zhang, D Li, RX Weng, Y Yu, R Gao, GY Xu - Neuron, 2024 - cell.com
Visceral and somatic pain serve as protective mechanisms against external threats.
Accumulated evidence has confirmed that the paraventricular hypothalamus (PVH) plays an …
Accumulated evidence has confirmed that the paraventricular hypothalamus (PVH) plays an …
PACAP and its role in primary headaches
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a
wide range of functions, such as nociception and in primary headaches. Regarding its …
wide range of functions, such as nociception and in primary headaches. Regarding its …
Migraine and neuropeptides
J Tajti, D Szok, Z Majláth, B Tuka, A Csáti, L Vécsei - Neuropeptides, 2015 - Elsevier
Migraine is a common disabling neurovascular primary headache disorder. The
pathomechanism is not clear, but extensive preclinical and clinical studies are ongoing. The …
pathomechanism is not clear, but extensive preclinical and clinical studies are ongoing. The …
Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice
Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors (PAC1, VPAC)
are present in sensory neurons and vascular smooth muscle. PACAP infusion was found to …
are present in sensory neurons and vascular smooth muscle. PACAP infusion was found to …
PACAP38 and PAC1 receptor blockade: a new target for headache?
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed
neuropeptide involved in neuroprotection, neurodevelopment, nociception and …
neuropeptide involved in neuroprotection, neurodevelopment, nociception and …
CGRP and migraine: could PACAP play a role too?
Migraine is a debilitating neurological disorder that affects about 12% of the population. In
the past decade, the role of the neuropeptide calcitonin gene-related peptide (CGRP) in …
the past decade, the role of the neuropeptide calcitonin gene-related peptide (CGRP) in …
Parabrachial nucleus (PBn) pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the amygdala: implication for the sensory and behavioral effects of …
The intricate relationships that associate pain, stress responses and emotional behavior
have been well established. Acute stressful situations can decrease nociceptive sensations …
have been well established. Acute stressful situations can decrease nociceptive sensations …
Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes …
Background Imaging migraine premonitory studies show increased midbrain activation
consistent with the ventral tegmental area, an area involved in pain modulation and hedonic …
consistent with the ventral tegmental area, an area involved in pain modulation and hedonic …