Dopamine is a prototypical neuromodulator that controls circuit function through G protein-
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …

Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons
and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory …

Neurotransmitters are chemicals that are secreted by neurons and relay messages to target
cells. The goal of in vivo electrochemistry is to provide a real-time view of neurotransmitters …

The basis for selective death of specific neuronal populations in neurodegenerative
diseases remains unclear. Parkinson's disease (PD) is a synucleinopathy characterized by a …

This review covers recent developments in the cellular neurophysiology of retrograde
signaling in the mammalian central nervous system. Normally at a chemical synapse a …

J. Neurochem.(2011) 116, 164–176. Abstract It is now recognized that trace amine
associated‐receptor 1 (TAAR1) plays a functional role in the regulation of brain …

Dopamine (DA) is a key transmitter in the basal ganglia, yet DA transmission does not
conform to several aspects of the classic synaptic doctrine. Axonal DA release occurs …

The endogenous cannabinoid system has been shown to play a crucial role in controlling
neuronal excitability and synaptic transmission. In this study we investigated the effects of a …

Modeling of the basal ganglia has played a major role in our understanding of this elusive
group of nuclei. Models of the basal ganglia have undergone evolutionary and revolutionary …