The hammerhead is the smallest of the nucleolytic ribozymes, that undergo backbone
cleavage by a transesterification reaction in the presence of magnesium ions. The RNA is …

▪ Abstract The hammerhead ribozyme is a small catalytic RNA that cleaves a target
phosphodiester bond in a reaction dependent on divalent metal ions. Crystal structures of …

For the understanding of the catalytic function of the RNA hammerhead ribozyme, a three-
dimensional model is essential but neither a crystal nor a solution structure has been …

We have used nucleobase substitution and kinetic analysis to test the hypothesis that
hammerhead catalysis occurs by a general acid− base mechanism, in which nucleobases …

The ion‐induced folding transitions of the hammerhead ribozyme have been analysed by
fluorescence resonance energy transfer. The hammerhead ribozyme may be regarded as a …

Bulges represent one of the most common non-helical elements in RNA, often displaying a
strong degree of phylogenetic conservation, both in location and sequence, within larger …

The Bacillus stearothermophilus ribosomal protein S15 binds to the central domain of the 16
S rRNA inducing a conformational change in a three-way helical junction. To understand the …

Here we investigate the global conformation of the hammerhead ribozyme. Electrophoretic
studies demonstrate that the structure is folded in response to the concentration and type of …

The trans-activation response element (TAR) found near the 5'end of the viral RNA of the
human immunodeficiency virus contains a 3-nt bulge that is recognized by the virally …

To investigate the relationship between RNA folding and ribozyme catalysis, we have
carried out a detailed kinetic analysis of four structural derivatives of the hairpin ribozyme …