Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management

JS Knight, DW Branch, TL Ortel - bmj, 2023 - bmj.com
Antiphospholipid syndrome (APS) is a thrombo-inflammatory disease propelled by
circulating autoantibodies that recognize cell surface phospholipids and phospholipid …

Cardiovascular disease risk in antiphospholipid syndrome: Thrombo-inflammation and atherothrombosis

MG Tektonidou - Journal of Autoimmunity, 2022 - Elsevier
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence
of antiphospholipid antibodies (aPL)(lupus anticoagulant, anticardiolipin antibodies and anti …

Anti–neutrophil extracellular trap antibodies in antiphospholipid antibody–positive patients: results from the antiphospholipid syndrome alliance for clinical trials and …

Y Zuo, S Navaz, A Tsodikov, K Kmetova… - Arthritis & …, 2023 - Wiley Online Library
Objective This study aimed to elucidate the presence, antigen specificities, and potential
clinical associations of anti–neutrophil extracellular trap (anti‐NET) antibodies in a …

Persistence of neutrophil extracellular traps and anticardiolipin auto‐antibodies in post‐acute phase COVID‐19 patients

E Pisareva, S Badiou, L Mihalovičová… - Journal of Medical …, 2023 - Wiley Online Library
In the early phase of the pandemic, we were among the first to postulate that neutrophil
extracellular traps (NETs) play a key role in COVID‐19 pathogenesis. This exploratory …

Neutrophil extracellular trap: A key player in the pathogenesis of autoimmune diseases

M Sadeghi, S Dehnavi, T Jamialahmadi… - International …, 2023 - Elsevier
Numerous studies suggest that neutrophils might have a crucial role in the pathogenesis of
systemic autoimmune diseases through neutrophil extracellular trap (NET) formation …

Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome

A Tambralli, A Harbaugh, SK NaveenKumar… - The Journal of Clinical …, 2024 - jci.org
Neutrophil hyperactivity and neutrophil extracellular trap release (NETosis) appear to play
important roles in the pathogenesis of the thromboinflammatory autoimmune disease known …

Whole blood transcriptome identifies interferon-regulated genes as key drivers in thrombotic primary antiphospholipid syndrome

KM Verrou, PP Sfikakis, MG Tektonidou - Journal of Autoimmunity, 2023 - Elsevier
Objective Pathogenesis of antiphospholipid syndrome (APS) isn't fully elucidated. We aimed
to identify gene signatures characterizing thrombotic primary APS (thrPAPS) and subgroups …

Prevalence of antiphospholipid antibodies and association with incident cardiovascular events

Y Zuo, S Navaz, W Liang, C Li, CR Ayers… - JAMA Network …, 2023 - jamanetwork.com
Importance The prevalence of antiphospholipid antibodies (aPL) and their association with
future atherosclerotic cardiovascular disease (ASCVD) risk has yet to be thoroughly …

[HTML][HTML] Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans

RA Ali, VC Minarchick, M Zahavi, CE Rysenga… - JCI insight, 2023 - ncbi.nlm.nih.gov
We previously reported that treatment of mice with 6-gingerol, the most abundant
phytochemical in ginger root, leads to phosphodiesterase inhibition that counteracts …

Beta 2 glycoprotein I and neutrophil extracellular traps: potential bridge between innate and adaptive immunity in anti-phospholipid syndrome

C Grossi, N Capitani, M Benagiano, CT Baldari… - Frontiers in …, 2023 - frontiersin.org
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by
recurrent vascular thrombosis and miscarriages in the absence of known causes. Antibodies …