Alkaloids mimicking the structures of monosaccharides are now believed to be widespread
in plants and microorganisms, and these sugar mimics inhibit glycosidases because of a …

Glycoside trimming enzymes are crucially important in a broad range of metabolic pathways,
including glycoprotein and glycolipid processing and carbohydrate digestion in the intestinal …

Iminosugars comprise the most attractive class of carbohydrate mimetics reported to date
and are ideally positioned to take advantage of our increasing understanding of …

The locations of distant secondary tumors in many clinical cancers and animal tumors are
nonrandom, and their distributions cannot be explained by simple anatomical or mechanical …

There is a need for anticancer agents with novel mechanisms of action. Recently identified
molecular targets for new anticancer agents include inducers of cell differentiation, cell cycle …

That metastases form by way of a complex series of sequential steps involving specific tumor
cell and host properties is now widely accepted [1-8]. Typically, these are the growth and …

This review focuses on the recent advances in investigations of the role of cell surface
carbohydrates in tumor metastasis. It also summarizes the results of extensive studies of …

Phytochemicals are constitutive metabolites that enable plants to overcome temporary or
continuous threats integral to their environment, while also controlling essential functions of …

Changes in the glycosylation of asparagine-linked oligosaccharides have been shown in
various tumor cells, including human colon cancer. Attempts were made to elucidate the …

Castanospermine (1, 6, 7, 8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that
modifies glycosylation by inhibiting alpha-glucosidase I. Castanospermine is shown to …