The initiation of mammalian embryonic transcription: to begin at the beginning
Gamete (sperm and oocyte) genomes are transcriptionally silent until embryonic genome
activation (EGA) following fertilization. EGA in humans had been thought to occur around the …
activation (EGA) following fertilization. EGA in humans had been thought to occur around the …
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3
In mammalian genomes, differentially methylated regions (DMRs) and histone marks
including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are …
including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are …
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency
M Werner-Klein, A Grujovic, C Irlbeck… - Nature …, 2020 - nature.com
Although thousands of breast cancer cells disseminate and home to bone marrow until
primary surgery, usually less than a handful will succeed in establishing manifest …
primary surgery, usually less than a handful will succeed in establishing manifest …
[HTML][HTML] A program of successive gene expression in mouse one-cell embryos
At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The
ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for …
ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for …
On mammalian totipotency: what is the molecular underpinning for the totipotency of zygote?
K Hu - Stem Cells and Development, 2019 - liebertpub.com
The mammalian zygote is described as a totipotent cell in the literature, but this
characterization is elusive ignoring the molecular underpinnings. Totipotency can connote …
characterization is elusive ignoring the molecular underpinnings. Totipotency can connote …
Caput epididymidal mouse sperm support full development
Mammalian sperm are produced in the testis as immature precursors that undergo complex
modifications and acquire forward motility during their subsequent transit through an …
modifications and acquire forward motility during their subsequent transit through an …
Tracking intracellular forces and mechanical property changes in mouse one-cell embryo development
Cells comprise mechanically active matter that governs their functionality, but intracellular
mechanics are difficult to study directly and are poorly understood. However, injected …
mechanics are difficult to study directly and are poorly understood. However, injected …
In vitro production of (Farm) animal embryos
C Wrenzycki - Animal Biotechnology 1: Reproductive Biotechnologies, 2018 - Springer
Over the past decades, in vitro production (IVP) of bovine embryos has been significantly
improved, and in particular bovine IVP is now widely applied under field conditions. This in …
improved, and in particular bovine IVP is now widely applied under field conditions. This in …
How can zygotes segregate entire parental genomes into distinct blastomeres? The zygote metaphase revisited
Zygote cytokinesis produces two symmetric blastomeres, which contain one copy of each
parental genome. Contrary to this dogma, we recently discovered that mammalian zygotes …
parental genome. Contrary to this dogma, we recently discovered that mammalian zygotes …
The future of embryoids from a reproductive science perspective
M Boiani… - Molecular Human …, 2024 - academic.oup.com
Background In mammalian biology, is there a point at which a given generation begins?
Historically, the answer was straightforward: it begins with the single-celled embryo, or …
Historically, the answer was straightforward: it begins with the single-celled embryo, or …