Major depression is a highly prevalent condition, affecting approximately 10% of the
population. 1 It is also a growing global problem, 2 and has been consistently associated …

Newer generation antidepressant drugs (ADs) are widely used as the first line of treatment
for major depressive disorders and are considered to be safer than tricyclic agents. In this …

Abstract The Research Domain Criteria (RDoC), developed by the National Institute of
Mental Health as a neuroscience-informed alternative to traditional psychiatric nosology, is …

Depression's burden of disease goes beyond functioning and quality of life and extends to
somatic health. Results from longitudinal cohort studies converge in illustrating that major …

Randomized trials have shown that selective serotonin reuptake inhibitors (SSRIs) and
serotonin-norepinephrine reuptake inhibitors (SNRIs) have better safety profiles than …

Rumination about the past and worries about the future (perseverative cognition) are
extremely common, although pervasive and distressing, dysfunctional cognitive processes …

Researchers have increasingly begun to use consumer wearables or wrist-worn
smartwatches and fitness monitors for measurement of cardiovascular psychophysiological …

Highlights•RSA is a valid and reliable biomarker of emotion regulation capacity in
humans.•Low tonic RSA and excessive RSA reactivity to emotion evocation mark PFC …

As the influence of diet on health may take place over a period of decades, there is a need
for biomarkers that help to identify those aspects of nutrition that have either a positive or a …

This article reviews central nervous system substrates and autonomic correlates of emotion
dysregulation and offers several suggestions for future research. Studies conducted in the …