Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

High-throughput studies of biological systems are rapidly accumulating a wealth of'omics'-
scale data. Visualization is a key aspect of both the analysis and understanding of these …

Motivation Reactome is a free, open-source, open-data, curated and peer-reviewed
knowledge base of biomolecular pathways. Pathways are arranged in a hierarchical …

Abstract Summary High Throughput Sequencing provides a cost effective means of
generating high resolution data for hundreds or even thousands of strains, and is rapidly …

Background With the decrease of DNA sequencing costs, sequence-based ty** methods
are rapidly becoming the gold standard for epidemiological surveillance. These methods …

Computational analysis and interactive visualization of biological networks and protein
structures are common tasks for gaining insight into biological processes. This protocol …

Pathway analysis is a set of widely used tools for research in life sciences intended to give
meaning to high-throughput biological data. The methodology of these tools settles in the …

Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) provides
information about interactions between environmental chemicals and gene products and …

Network analysis has an increasing role in our effort to understand the complexity of
biological systems. This is because of our ability to generate large data sets, where the …

The limitations of genome-wide association (GWA) studies that focus on the phenotypic
influence of common genetic variants have motivated human geneticists to consider the …