Fibroblast activation protein (FAP)-targeted CAR-T cells: launching an attack on tumor stroma
R Bughda, P Dimou, RR D'Souza… - ImmunoTargets and …, 2021 - Taylor & Francis
Fibroblast activation protein (FAP) is a membrane protease that is highly expressed by
cancer-associated fibroblasts (CAFs). FAP can modulate the tumor microenvironment (TME) …
cancer-associated fibroblasts (CAFs). FAP can modulate the tumor microenvironment (TME) …
Epidermal growth factor receptor targeting in cancer: a review of trends and strategies
The epidermal growth factor receptor (EGFR) is a cell-surface receptor belonging to ErbB
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed …
Purpose Immunologic targeting of tumor-specific gene mutations may allow precise
eradication of neoplastic cells without toxicity. Epidermal growth factor receptor variant III …
eradication of neoplastic cells without toxicity. Epidermal growth factor receptor variant III …
The epidermal growth factor receptor variant III (EGFR v III): where wild things are altered
HK Gan, AN Cvrljevic, TG Johns - The FEBS journal, 2013 - Wiley Online Library
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human
epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene …
epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene …
Epidermal growth factor receptor in non–small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis
FR Hirsch, M Varella-Garcia, PA Bunn Jr… - Journal of clinical …, 2003 - ascopubs.org
Purpose: The epidermal growth factor receptor (EGFR) is frequently overexpressed in non–
small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic …
small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic …
The epidermal growth factor receptor family: biology driving targeted therapeutics
MJ Wieduwilt, MM Moasser - Cellular and molecular life sciences, 2008 - Springer
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
Rindopepimut with bevacizumab for patients with relapsed EGFRvIII-expressing glioblastoma (ReACT): results of a double-blind randomized phase II trial
DA Reardon, A Desjardins, JJ Vredenburgh… - Clinical Cancer …, 2020 - AACR
Purpose: Rindopepimut is a vaccine targeting the tumor-specific EGF driver mutation,
EGFRvIII. The ReACT study investigated whether the addition of rindopepimut to standard …
EGFRvIII. The ReACT study investigated whether the addition of rindopepimut to standard …
EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss
Purpose: Chimeric antigen receptor (CAR) transduced T cells represent a promising
immune therapy that has been shown to successfully treat cancers in mice and humans …
immune therapy that has been shown to successfully treat cancers in mice and humans …
Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials
BR Voldborg, L Damstrup, M Spang-Thomsen… - Annals of …, 1997 - Elsevier
The epidermal growth factor receptor (EGFR) is a growth factor receptor that induces cell
differentiation and proliferation upon activation through the binding of one of its ligands. The …
differentiation and proliferation upon activation through the binding of one of its ligands. The …
EGFRvIII antibody–conjugated iron oxide nanoparticles for magnetic resonance imaging–guided convection-enhanced delivery and targeted therapy of glioblastoma
CG Hadjipanayis, R Machaidze, M Kaluzova, L Wang… - Cancer research, 2010 - AACR
The magnetic nanoparticle has emerged as a potential multifunctional clinical tool that can
provide cancer cell detection by magnetic resonance imaging (MRI) contrast enhancement …
provide cancer cell detection by magnetic resonance imaging (MRI) contrast enhancement …