Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

Individuals addicted to drugs of abuse such as alcohol, nicotine, cocaine, and heroin are a
significant burden on healthcare systems all over the world. The positive reinforcing …

Abstract l‐glutamate is the predominant excitatory neurotransmitter in the CNS and has a
central role in a variety of brain functions. The termination of glutamate neurotransmission by …

Astrocytes provide support for neurons, regulate metabolic processes, and influence
neuronal communication in a variety of ways, including through the homeostatic regulation …

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …

Emerging evidence indicates that dysfunctional glutamate neurotransmission is critical in the
initiation and development of alcohol and drug dependence. Alcohol consumption induced …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

Dysregulation of glutamate homeostasis is a well-established core feature of
neuropsychiatric disorders. Extracellular glutamate concentration is regulated by glutamate …

Long-term treatment with ceftriaxone attenuates the reinstatement of cocaine seeking while
increasing the function of the glutamate transporter 1 (GLT-1) and system xC-(Sxc) in the …