Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at
different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and …

Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …

Objective The purpose of this study was to compare intraamniotic inflammation vs microbial
invasion of the amniotic cavity (MIAC) as predictors of adverse outcome in preterm labor with …

Please cite this paper as: Conde‐Agudelo A, Papageorghiou A, Kennedy S, Villar J. Novel
biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic …

Introduction: Intra-amniotic inflammation is traditionally defined as an elevation of amniotic
fluid interleukin (IL)-6. Previous case control studies have suggested an association …

Preterm birth is defined as delivery before 37 weeks' gestation. In 2010, the incidence of
preterm birth in the United States was 12.3% 1 and ranged from 8% to 12% in developed …

Objective: Among patients presenting with preterm labor and intact membranes, those with
intra-amniotic inflammation have adverse obstetrical and neonatal outcomes. The diagnosis …

In 1998, a systemic fetal cytokine response, defined as a plasma interleukin-6 (IL-6) value
above 11 pg/mL, was reported to be a major independent risk factor for the subsequent …

Background Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm
prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this …

Problem Preterm birth is commonly preceded by preterm labor, a syndrome that is causally
linked to both intra‐amniotic infection and intra‐amniotic inflammation. However, the …