Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

BACKGROUND The human brain contains about 100 billion neurons, each of which makes
thousands of synaptic connections. Although individual neurons can themselves be …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

Psilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints
that the use of psychedelics can produce neural adaptations, although the extent and …

The Cre/lox system is widely used in mice to achieve cell-type-specific gene expression.
However, a strong and universally responding system to express genes under Cre control is …

The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals
1. Unlike most medications for the treatment of substance use disorders, anecdotal reports …

The visualization of molecularly labeled structures within large intact tissues in three
dimensions is an area of intense focus. We describe a simple, rapid, and inexpensive …

In optical microscopy, fine structural details are resolved by using refraction to magnify
images of a specimen. We discovered that by synthesizing a swellable polymer network …

Obtaining high-resolution information from a complex system, while maintaining the global
perspective needed to understand system function, represents a key challenge in biology …

With few exceptions biological tissues strongly scatter light, making high-resolution deep
imaging impossible for traditional—including confocal—fluorescence microscopy. Nonlinear …