Cell-surface interactions on arginine-rich cell-penetrating peptides allow for multiplex modes of internalization

S Futaki, I Nakase - Accounts of chemical research, 2017 - ACS Publications
Conspectus One of the recent hot topics in peptide-related chemical biology research is the
potential of cell-penetrating peptides (CPPs). Owing to their ability to deliver exogenous …

The uptake of arginine-rich cell-penetrating peptides: putting the puzzle together

R Brock - Bioconjugate chemistry, 2014 - ACS Publications
Over the past 20 years, cell-penetrating peptides (CPPs) have captured the attention of
biomedical researchers, biophysicists, and (bio) organic chemists. These molecules …

Cell-surface-retained peptide additives for the cytosolic delivery of functional proteins

JVV Arafiles, J Franke, L Franz… - Journal of the …, 2023 - ACS Publications
The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …

Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system

I Szabó, M Yousef, D Soltész, C Bató, G Mező… - Pharmaceutics, 2022 - mdpi.com
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Current understanding of direct translocation of arginine-rich cell-penetrating peptides and its internalization mechanisms

T Takeuchi, S Futaki - Chemical and Pharmaceutical Bulletin, 2016 - jstage.jst.go.jp
Arginine-rich cell-penetrating peptides (CPPs) including Tat, Penetratin and oligoarginine
peptides are a series of short peptides that can be efficiently internalized into cells and have …

Studies of cell-penetrating peptides by biophysical methods

M Zorko, Ü Langel - Quarterly Reviews of Biophysics, 2022 - cambridge.org
Biophysical studies have a very high impact on the understanding of internalization,
molecular mechanisms, interactions, and localization of CPPs and CPP/cargo conjugates in …

Ionic strength and solution composition dictate the adsorption of cell-penetrating peptides onto phosphatidylcholine membranes

MTH Nguyen, D Biriukov, C Tempra, K Baxova… - Langmuir, 2022 - ACS Publications
Adsorption of arginine-rich positively charged peptides onto neutral zwitterionic
phosphocholine (PC) bilayers is a key step in the translocation of those potent cell …

Loosening of lipid packing promotes oligoarginine entry into cells

T Murayama, T Masuda, S Afonin… - Angewandte …, 2017 - Wiley Online Library
Despite extensive use of arginine‐rich cell‐penetrating peptides (CPPs)—including
octaarginine (R8)—as intracellular delivery vectors, mechanisms for their internalization are …

Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells

Y Kawaguchi, S Futaki - Current Opinion in Chemical Biology, 2024 - Elsevier
The delivery of functional proteins, including antibodies, into cells opens up many
opportunities to regulate cellular events, with significant implications for studies in chemical …

Importance of net hydrophobicity in the cellular uptake of all-hydrocarbon stapled peptides

K Sakagami, T Masuda, K Kawano… - Molecular …, 2018 - ACS Publications
All-hydrocarbon stapled peptides make up a promising class of protein–protein interaction
regulators; their potential therapeutic benefit arises because they have a high binding affinity …