Roles of secreted phospholipase A2 group IIA in inflammation and host defense
E Dore, E Boilard - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2019 - Elsevier
Among all members of the secreted phospholipase A 2 (sPLA 2) family, group IIA sPLA 2
(sPLA 2-IIA) is possibly the most studied enzyme. Since its discovery, many names have …
(sPLA 2-IIA) is possibly the most studied enzyme. Since its discovery, many names have …
Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing
L **ang, J Liang, Z Wang, F Lin, Y Zhuang… - Science …, 2023 - science.org
Mechanical activation of fibroblasts, caused by friction and transforming growth factor–β1
recognition, is one of the main causes of tissue adhesions. In this study, we developed a …
recognition, is one of the main causes of tissue adhesions. In this study, we developed a …
[HTML][HTML] Secreted phospholipases A2-not just enzymes: Revisited
A Ivanušec, J Šribar, I Križaj - International Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological
processes through their enzymatic activity and as ligands for membrane and soluble …
processes through their enzymatic activity and as ligands for membrane and soluble …
Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats
MÁ Rincón-Cervera, R Valenzuela… - … and Essential Fatty …, 2016 - Elsevier
Abstract Alpha-linolenic acid (C18: 3 n-3, ALA) is an essential fatty acid and the metabolic
precursor of long-chain polyunsaturated fatty acids (LCPUFA) from the n-3 family with …
precursor of long-chain polyunsaturated fatty acids (LCPUFA) from the n-3 family with …
Supplementation with antioxidant-rich extra virgin olive oil prevents hepatic oxidative stress and reduction of desaturation capacity in mice fed a high-fat diet: Effects …
MA Rincón-Cervera, R Valenzuela… - Nutrition, 2016 - Elsevier
Objective The aim of this study was to assess the effect of dietary supplementation with extra
virgin olive oil (EVOO) in mice on the reduction of desaturase and antioxidant enzymatic …
virgin olive oil (EVOO) in mice on the reduction of desaturase and antioxidant enzymatic …
Reduction in the desaturation capacity of the liver in mice subjected to high fat diet: Relation to LCPUFA depletion in liver and extrahepatic tissues
R Valenzuela, C Barrera, A Espinosa, P Llanos… - … and Essential Fatty …, 2015 - Elsevier
Abstract α-Linolenic (ALA) and linoleic (LA) acids are precursors of long chain
polyunsaturated fatty acids (LCPUFAs), FAs with important biochemical and physiological …
polyunsaturated fatty acids (LCPUFAs), FAs with important biochemical and physiological …
Structural and Functional Aspects of Targeting the Secreted Human Group IIA Phospholipase A2
RR Kim, Z Chen, T J. Mann, K Bastard, K F. Scott… - Molecules, 2020 - mdpi.com
Human group IIA secretory phospholipase A2 (hGIIA) promotes the proliferation of cancer
cells, making it a compelling therapeutic target, but it is also significant in other inflammatory …
cells, making it a compelling therapeutic target, but it is also significant in other inflammatory …
Snake venom phospholipase A2 toxins
B Lomonte, I Križaj - Handbook of venoms and toxins of reptiles, 2021 - taylorfrancis.com
Secreted phospholipases A2 (sPLA2s) are almost universally expressed in snake venoms,
often representing a major portion of their protein components. Snake venom sPLA2s …
often representing a major portion of their protein components. Snake venom sPLA2s …
[HTML][HTML] Binding of a Naja naja venom acidic phospholipase A2 cognate complex to membrane-bound vimentin of rat L6 cells: Implications in cobra venom-induced …
An acidic phospholipase A 2 enzyme (NnPLA 2-I) interacts with three finger toxins (cytotoxin
and neurotoxin) from Naja naja venom to form cognate complexes to enhance its cytotoxicity …
and neurotoxin) from Naja naja venom to form cognate complexes to enhance its cytotoxicity …
Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2
M Mangini, R D'angelo, C Vinciguerra… - Frontiers in Cell and …, 2022 - frontiersin.org
Increasing evidence points to the involvement of group IIA secreted phospholipase A2
(sPLA2-IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity …
(sPLA2-IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity …