microRNAs in action: biogenesis, function and regulation

R Shang, S Lee, G Senavirathne, EC Lai - Nature Reviews Genetics, 2023 - nature.com
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

Emerging roles and functional mechanisms of PIWI-interacting RNAs

X Wang, A Ramat, M Simonelig, MF Liu - Nature Reviews Molecular …, 2023 - nature.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

Reexamining assumptions about miRNA-guided gene silencing

A Kilikevicius, G Meister, DR Corey - Nucleic acids research, 2022 - academic.oup.com
MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to
regulate the expression of any RNA. This potential has led to the publication of several …

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

X Shen, DR Corey - Nucleic acids research, 2018 - academic.oup.com
RNA plays a central role in the expression of all genes. Because any sequence within RNA
can be recognized by complementary base pairing, synthetic oligonucleotides and …

Structural basis for guide RNA processing and seed-dependent DNA targeting by CRISPR-Cas12a

DC Swarts, J van der Oost, M **ek - Molecular cell, 2017 - cell.com
The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome
editing, possesses two distinct nuclease activities: endoribonuclease activity for processing …

A network-biology perspective of microRNA function and dysfunction in cancer

CP Bracken, HS Scott, GJ Goodall - Nature Reviews Genetics, 2016 - nature.com
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …

Regulation of microRNA biogenesis

M Ha, VN Kim - Nature reviews Molecular cell biology, 2014 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

[HTML][HTML] A structural view of miRNA biogenesis and function

AL Leitão, FJ Enguita - Non-coding RNA, 2022 - mdpi.com
Micro-RNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) that act as post-
transcriptional regulators of gene expression. Since their discovery in 1993, they have been …

Diversifying microRNA sequence and function

SL Ameres, PD Zamore - Nature reviews Molecular cell biology, 2013 - nature.com
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …

Molecular mechanisms of RNA interference

RC Wilson, JA Doudna - Annual review of biophysics, 2013 - annualreviews.org
Small RNA molecules regulate eukaryotic gene expression during development and in
response to stresses including viral infection. Specialized ribonucleases and RNA-binding …