Advancing therapy for neuroblastoma
B Qiu, KK Matthay - Nature Reviews Clinical Oncology, 2022 - nature.com
Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …
ranging from localized or spontaneously regressing to widely metastatic disease …
Recent advances in the developmental origin of neuroblastoma: an overview
M Ponzoni, T Bachetti, MV Corrias, C Brignole… - Journal of Experimental …, 2022 - Springer
Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …
undergoing a defective differentiation due to genomic and epigenetic impairments …
Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia
ND Anderson, J Birch, T Accogli, I Criado… - Nature Medicine, 2023 - nature.com
In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia
(R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable …
(R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable …
Neuroblastoma: When differentiation goes awry
M Zeineldin, AG Patel, MA Dyer - Neuron, 2022 - cell.com
Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …
Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis
IS Fetahu, W Esser-Skala, R Dnyansagar… - Nature …, 2023 - nature.com
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …
Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome
Neuroblastoma, the most frequent solid tumor in infants, shows very diverse outcomes from
spontaneous regression to fatal disease. When these different tumors originate and how …
spontaneous regression to fatal disease. When these different tumors originate and how …
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia
Abstract KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor
prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell …
prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell …
Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma
Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
Identifying tumor cells at the single-cell level using machine learning
Tumors are complex tissues of cancerous cells surrounded by a heterogeneous cellular
microenvironment with which they interact. Single-cell sequencing enables molecular …
microenvironment with which they interact. Single-cell sequencing enables molecular …
IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
Background Neuroblastoma is the most common solid tumor in infants accounting for
approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma …
approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma …