Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era
HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes
Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
Global map** of small RNA-target interactions in bacteria
Small RNAs (sRNAs) associated with the RNA chaperon protein Hfq are key
posttranscriptional regulators of gene expression in bacteria. Deciphering the sRNA-target …
posttranscriptional regulators of gene expression in bacteria. Deciphering the sRNA-target …
The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)
Individual Streptomyces species have the genetic potential to produce a diverse array of
natural products of commercial, medical and veterinary interest. However, these products …
natural products of commercial, medical and veterinary interest. However, these products …
Modeling leaderless transcription and atypical genes results in more accurate gene prediction in prokaryotes
In a conventional view of the prokaryotic genome organization, promoters precede operons
and ribosome binding sites (RBSs) with Shine-Dalgarno consensus precede genes …
and ribosome binding sites (RBSs) with Shine-Dalgarno consensus precede genes …
A novel enrichment strategy reveals unprecedented number of novel transcription start sites at single base resolution in a model prokaryote and the gut microbiome
Background The initiating nucleotide found at the 5'end of primary transcripts has a
distinctive triphosphorylated end that distinguishes these transcripts from all other RNA …
distinctive triphosphorylated end that distinguishes these transcripts from all other RNA …
70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria
According to the standard model of bacterial translation initiation, the small ribosomal 30S
subunit binds to the initiation site of an mRNA with the help of three initiation factors (IF1 …
subunit binds to the initiation site of an mRNA with the help of three initiation factors (IF1 …
Transposable element insertions shape gene regulation and melanin production in a fungal pathogen of wheat
P Krishnan, L Meile, C Plissonneau, X Ma… - BMC biology, 2018 - Springer
Background Fungal plant pathogens pose major threats to crop yield and sustainable food
production if they are highly adapted to their host and the local environment. Variation in …
production if they are highly adapted to their host and the local environment. Variation in …
Primary transcriptome and translatome analysis determines transcriptional and translational regulatory elements encoded in the Streptomyces clavuligerus genome
Determining transcriptional and translational regulatory elements in GC-rich Streptomyces
genomes is essential to elucidating the complex regulatory networks that govern secondary …
genomes is essential to elucidating the complex regulatory networks that govern secondary …
Pervasive translation in Mycobacterium tuberculosis
C Smith, JG Canestrari, AJ Wang, MM Champion… - Elife, 2022 - elifesciences.org
Most bacterial ORFs are identified by automated prediction algorithms. However, these
algorithms often fail to identify ORFs lacking canonical features such as a length of> 50 …
algorithms often fail to identify ORFs lacking canonical features such as a length of> 50 …