Cystic fibrosis (CF) is a genetic disease with mutational changes leading to profound
dysbiosis, both pulmonary and intestinal, from a very young age. This dysbiosis plays an …

Discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene was the
long-awaited scientific advance that dramatically improved the diagnosis and treatment of …

Background Because of the heterogeneity in cystic fibrosis (CF) lung disease among young
children, a clinical method to identify early‐onset lung disease is needed. Objective To …

The rapid pace of recent advancements in CF has led to significant improvements in patient
outcomes and has created new opportunities to personalize care decisions. Numerous …

Background & aims Children with cystic fibrosis (CF) are susceptible to fat-soluble vitamin
deficiencies unless supplemented, but even large doses of vitamin D may not prevent low …

Background Despite the growing awareness of cystic fibrosis (CF) in China, few cases have
been reported in Henan, which is the most populous province in the country. This study …

Mutations in the LMNA gene-encoding A-type lamins can cause Limb–Girdle muscular
dystrophy Type 1B (LGMD1B). This disease presents with weakness and wasting of the …

Human plasminogen (PLG), the zymogen of the fibrinolytic protease, plasmin, is a
polymorphic protein with two widely distributed codominant alleles, PLG/Asp453 and …

Vitamin D sufficiency has been difficult to achieve consistently in patients with cystic fibrosis
(CF), even with robust oral supplements. To assess vitamin D status and resistance to …

OBJECTIVE: To compare class I/II cystic fibrosis transmembrane conductance regulator
(CFTR) mutations to class III-V mutations with regards to cystic fibrosis disease severity …