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Preservation of duplicate genes by complementary, degenerative mutations
The origin of organismal complexity is generally thought to be tightly coupled to the
evolution of new gene functions arising subsequent to gene duplication. Under the classical …
evolution of new gene functions arising subsequent to gene duplication. Under the classical …
The snail superfamily of zinc-finger transcription factors
The Snail superfamily of zinc-finger transcription factors is involved in processes that imply
pronounced cell movements, both during embryonic development and in the acquisition of …
pronounced cell movements, both during embryonic development and in the acquisition of …
Spatial reconstruction of single-cell gene expression data
Spatial localization is a key determinant of cellular fate and behavior, but methods for
spatially resolved, transcriptome-wide gene expression profiling across complex tissues are …
spatially resolved, transcriptome-wide gene expression profiling across complex tissues are …
[HTML][HTML] Disruptive CHD8 mutations define a subtype of autism early in development
Autism spectrum disorder (ASD) is a heterogeneous disease in which efforts to define
subtypes behaviorally have met with limited success. Hypothesizing that genetically based …
subtypes behaviorally have met with limited success. Hypothesizing that genetically based …
[HTML][HTML] High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways
Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …
Stages of embryonic development of the zebrafish
We describe a series of stages for development of the embryo of the zebrafish, Danio
(Brachydanio) rerio. We define seven broad periods of embryogenesis—the zygote …
(Brachydanio) rerio. We define seven broad periods of embryogenesis—the zygote …
High-resolution in situ hybridization to whole-mount zebrafish embryos
C Thisse, B Thisse - Nature protocols, 2008 - nature.com
The in situ hybridization (ISH) technique allows the sites of expression of particular genes to
be detected. This protocol describes ISH of digoxigenin-labeled antisense RNA probes to …
be detected. This protocol describes ISH of digoxigenin-labeled antisense RNA probes to …
Proinflammatory signaling regulates hematopoietic stem cell emergence
Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the
lifetime of an organism. In vertebrate embryos, HSCs arise from the unique …
lifetime of an organism. In vertebrate embryos, HSCs arise from the unique …
Ontogeny and behaviour of early macrophages in the zebrafish embryo
P Herbomel, B Thisse, C Thisse - Development, 1999 - journals.biologists.com
In the zebrafish embryo, the only known site of hemopoieisis is an intra-embryonic blood
island at the junction between trunk and tail that gives rise to erythroid cells. Using video …
island at the junction between trunk and tail that gives rise to erythroid cells. Using video …
nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate
We report the isolation and identification of a new mutation affecting pigment cell fate in the
zebrafish neural crest. Homozygous nacre (nac w2) mutants lack melanophores throughout …
zebrafish neural crest. Homozygous nacre (nac w2) mutants lack melanophores throughout …