Biomarkers are measurable indicators of a biological state. As our understanding of
diseases meliorates, it is generally accepted that early diagnosis renders the best chance to …

This work discusses bioinformatics and experimental approaches to explore the human
proteome, a constellation of proteins expressed in different tissues and organs. As the …

Answer questions and earn CME/CNE Pancreatic cancer is currently one of the deadliest of
the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and …

Selected reaction monitoring (SRM) is a targeted mass spectrometry technique that is
emerging in the field of proteomics as a complement to untargeted shotgun methods. SRM is …

Somatic, gain-of-function mutations in ras genes were the first specific genetic alterations
identified in human cancer about 3 decades ago. Studies during the last quarter century …

Adoption of targeted mass spectrometry (MS) approaches such as multiple reaction
monitoring (MRM) to study biological and biomedical questions is well underway in the …

Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS
alters cancer cell behavior has been studied intensively, but non-cell autonomous effects of …

The identification of protein homologs in large databases using conventional methods, such
as protein sequence comparison, often misses remote homologs. Here, we offer an ultrafast …

Targeted mass spectrometry (MS) is becoming widely used in academia and in
pharmaceutical and biotechnology industries for sensitive and quantitative detection of …

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is pressing
public health systems around the world, and large population testing is a key step to control …