Hepatitis A is a vaccine-preventable infection caused by the hepatitis A virus (HAV). Over
150 million new infections of hepatitis A occur annually. HAV causes an acute inflammatory …

Excessive alcohol consumption is a global healthcare problem with enormous social,
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …

Chronic liver diseases usually developed through stepwise pathological transitions under
the persistent risk factors. The molecular changes during liver transitions are pivotal to …

Relatively little is known of the mechanisms underlying hepatitis A virus (HAV) genome
replication. Unlike other well-studied picornaviruses, HAV RNA replication requires the zinc …

The overexpression and misfolding of viral proteins in the endoplasmic reticulum (ER) may
cause cellular stress, thereby inducing a cytoprotective, proteostatic host response involving …

Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver
disease with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular …

Background & Aims Consistent with its relatively narrow host species range, hepatitis A virus
(HAV) cannot infect C57BL/6 mice. However, in Mavs-/-mice with genetic deficiency of the …

In 2018, there was a hepatitis A outbreak in Japan, and hepatitis A virus (HAV) infection is
considered a sexually transmitted disease. In general, patients with hepatitis A should be …

Hepatoviruses are atypical hepatotropic picornaviruses that are released from infected cells
without lysis in small membranous vesicles. These exosome-like, quasi-enveloped virions …

Hepatitis A virus (HAV) live-attenuated vaccine H2 strain has been approved for clinical use
for decades with ideal safety profiles in nonhuman primate models and humans. Recently …