Heavy metal toxicity: An update of chelating therapeutic strategies

JJ Kim, YS Kim, V Kumar - Journal of Trace elements in Medicine and …, 2019 - Elsevier
Aim This review illustrates heavy metals toxicity, currently available therapies and the role
and efficacy of chelation therapy for its management. Summary Heavy metals are necessary …

Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys

V Matović, A Buha, D Ðukić-Ćosić, Z Bulat - Food and Chemical Toxicology, 2015 - Elsevier
Besides being important occupational hazards, lead and cadmium are nowadays metals of
great environmental concern. Both metals, without any physiological functions, can induce …

Advances in metal-induced oxidative stress and human disease

K Jomova, M Valko - Toxicology, 2011 - Elsevier
Detailed studies in the past two decades have shown that redox active metals like iron (Fe),
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …

Toxicity of lead: a review with recent updates

G Flora, D Gupta, A Tiwari - Interdisciplinary toxicology, 2012 - sciendo.com
Lead poisoning has been recognized as a major public health risk, particularly in
develo** countries. Though various occupational and public health measures have been …

Chelation in metal intoxication

SJS Flora, V Pachauri - … journal of environmental research and public …, 2010 - mdpi.com
Chelation therapy is the preferred medical treatment for reducing the toxic effects of metals.
Chelating agents are capable of binding to toxic metal ions to form complex structures which …

Heavy metal induced oxidative stress & its possible reversal by chelation therapy

SJS Flora, M Mittal, A Mehta - Indian Journal of Medical Research, 2008 - journals.lww.com
Exposure to heavy metals is a common phenomenon due to their environmental
pervasiveness. Metal intoxication particularly neurotoxicity, genotoxicity, or carcinogenicity is …

Protective effects of chrysin against oxidative stress and inflammation induced by lead acetate in rat kidneys: a biochemical and histopathological approach

S Kucukler, F Benzer, S Yildirim, C Gur… - … Trace Element Research, 2021 - Springer
In this study, the protective effects of chrysin (CR) on lead acetate (PbAc)-induced renal
toxicity in Sprague-Dawley rats were investigated with biochemical, histopathological, and …

Chelation: harnessing and enhancing heavy metal detoxification—a review

ME Sears - The Scientific World Journal, 2013 - Wiley Online Library
Toxic metals such as arsenic, cadmium, lead, and mercury are ubiquitous, have no
beneficial role in human homeostasis, and contribute to noncommunicable chronic …

Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure

SJS Flora - Oxidative medicine and cellular longevity, 2009 - Wiley Online Library
Oxidative stress contributes to the pathophysiology of exposure to heavy metals/metalloid.
Beneficial renal effects of some medications, such as chelation therapy depend at least …

Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity.

L Patrick - Alternative medicine review, 2006 - search.ebscohost.com
Lead is an environmentally persistent toxin that causes neurological, hematological,
gastrointestinal, reproductive, circulatory, and immunological pathologies. The propensity for …