VEGF in signaling and disease: beyond discovery and development

RS Apte, DS Chen, N Ferrara - Cell, 2019 - cell.com
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our
understanding of vasculogenesis and angiogenesis during development and physiological …

Retinopathy of prematurity

J Chen, LEH Smith - Angiogenesis, 2007 - Springer
Retinopathy of prematurity (ROP) is a common blinding disease in children in the developed
world despite current treatment, and is becoming increasingly prevalent in the develo** …

Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis

KM Connor, NM Krah, RJ Dennison, CM Aderman… - Nature protocols, 2009 - nature.com
The mouse model of oxygen-induced retinopathy (OIR) has been widely used in studies
related to retinopathy of prematurity, proliferative diabetic retinopathy and in studies …

Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity

A Hellstrom, C Perruzzi, M Ju… - Proceedings of the …, 2001 - National Acad Sciences
Retinopathy of prematurity is a blinding disease, initiated by lack of retinal vascular growth
after premature birth. We show that lack of insulin-like growth factor I (IGF-I) in knockout mice …

An updated view on the role of dopamine in myopia

M Feldkaemper, F Schaeffel - Experimental eye research, 2013 - Elsevier
A large body of data is available to support the hypothesis that dopamine (DA) is one of the
retinal neurotransmitters involved in the signaling cascade that controls eye growth by …

Retinopathy of prematurity: a global perspective and recent developments

K Sabri, AL Ells, EY Lee, S Dutta, A Vinekar - Pediatrics, 2022 - publications.aap.org
Retinopathy of prematurity (ROP) is a significant cause of potentially preventable blindness
in preterm infants worldwide. It is a disease caused by abnormal retinal vascularization that …

Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity

EA Pierce, ED Foley, LEH Smith - Archives of ophthalmology, 1996 - jamanetwork.com
Objectives: To investigate the role of vascular endothelial growth factor (VEGF) in the
pathogenesis of the first phase of retinopathy of prematurity (ROP) and to examine the …

Lutein supplementation for eye diseases

LH Li, JCY Lee, HH Leung, WC Lam, Z Fu, ACY Lo - Nutrients, 2020 - mdpi.com
Lutein is one of the few xanthophyll carotenoids that is found in high concentration in the
macula of human retina. As de novo synthesis of lutein within the human body is impossible …

Animal models of diabetic retinopathy: summary and comparison

AKW Lai, ACY Lo - Journal of diabetes research, 2013 - Wiley Online Library
Diabetic retinopathy (DR) is a microvascular complication associated with chronic exposure
to hyperglycemia and is a major cause of blindness worldwide. Although clinical …

Pathogenesis of retinopathy of prematurity

LEH Smith - Growth hormone & IGF research, 2004 - Elsevier
Retinopathy of prematurity (ROP) is a major cause of blindness in children in developed
countries. ROP is a two-phase disease, beginning with delayed retinal vascular growth after …