Despite long-term and widespread use of deep brain stimulation (DBS) in a variety of
neurological conditions, the underlying mechanisms of action have been elusive. Growing …

Intrinsic coupling constitutes a key feature of ongoing brain activity, which exhibits rich
spatiotemporal patterning and contains information that influences cognitive processing. We …

The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …

Oscillations form a ubiquitous feature of the central nervous system. Evidence is accruing
from cortical and sub-cortical recordings that these rhythms may be functionally important …

In patients with Parkinson's disease and in animal models of this disorder, neurons in the
basal ganglia and related regions in thalamus and cortex show changes that can be …

Subthalamic nucleus deep brain stimulation (STN DBS) relieves many motor symptoms of
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …

In Parkinson's disease, an increase in beta oscillations within the basal ganglia nuclei has
been shown to be associated with difficulty in movement initiation. An important role in the …

Abnormal cortical oscillations are markers of Parkinson's Disease (PD). Transcranial
alternating current stimulation (tACS) can modulate brain oscillations and possibly impact on …

Deep brain stimulation (DBS) has been used as a treatment of movement disorders such as
Parkinson's disease, dystonia, and essential tremor for over twenty years, and is a promising …

The dynamical properties of cortico-basal ganglia (CBG) circuits are dramatically altered
following the loss of dopamine in Parkinson's disease (PD). The neural circuit dysfunctions …