Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity
During RNA replication, coronaviruses require proofreading to maintain the integrity of their
large genomes. Nsp14 associates with viral polymerase complex to excise the mismatched …
large genomes. Nsp14 associates with viral polymerase complex to excise the mismatched …
Oligomeric State of β-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering
The β-coronavirus family, encompassing Severe Acute Respiratory Syndrome Coronavirus
2 (SARS-CoV-2), Severe Acute Respiratory Syndrome Coronavirus (SARS), and Middle …
2 (SARS-CoV-2), Severe Acute Respiratory Syndrome Coronavirus (SARS), and Middle …
The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity
SL Grimes, BE Heaton, ML Anderson, K Burke… - Journal of …, 2025 - journals.asm.org
Coronaviruses (CoVs) encode non-structural proteins (nsp's) 1–16, which assemble to form
replication-transcription complexes that function in viral RNA synthesis. All CoVs encode a …
replication-transcription complexes that function in viral RNA synthesis. All CoVs encode a …
Substrate specificity and kinetics of RNA hydrolysis by SARS-CoV-2 NSP10/14 exonuclease
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes
COVID-19, continues to evolve resistance to vaccines and existing antiviral therapies at an …
COVID-19, continues to evolve resistance to vaccines and existing antiviral therapies at an …
A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
M Klein, A Das, SC BERA, TK Anderson, D Kocincova… - bioRxiv, 2025 - biorxiv.org
Coronaviruses (CoV) encode sixteen non-structural proteins (nsps), most of which form the
replication-transcription complex (RTC). The RTC contains a core composed of one nsp12 …
replication-transcription complex (RTC). The RTC contains a core composed of one nsp12 …
Oligomeric state of β-coronavirus non-structural protein 10 stimulators studied by OmniSEC and Small Angle X-ray Scattering
Members of the β-coronavirus family such as SARS-CoV-2, SARS, and MERS have caused
pandemics over the last 20 years. Future pandemics are likely and studying the coronavirus …
pandemics over the last 20 years. Future pandemics are likely and studying the coronavirus …
[HTML][HTML] Coronavirus 2′-O-methyltransferase: A promising therapeutic target
Coronaviruses (CoVs) have been the source of multiple epidemics and a global pandemic
since the start of century, and there is an urgent need to understand CoV biology and …
since the start of century, and there is an urgent need to understand CoV biology and …